A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report

Clozapine is recommended for patients with schizophrenia and tardive dystonia (TD); however, the appropriate dose remains unclear. In this case, a low dose (150 mg/day) of clozapine improved refractory TD and further ameliorated psychiatric symptoms. Herein, we report on a 41-year-old female with sc...

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Autores principales: Okamoto, Naomichi, Konishi, Yuki, Tesen, Hirofumi, Ikenouchi, Atsuko, Yoshimura, Reiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057797/
https://www.ncbi.nlm.nih.gov/pubmed/33889030
http://dx.doi.org/10.2147/IMCRJ.S307410
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author Okamoto, Naomichi
Konishi, Yuki
Tesen, Hirofumi
Ikenouchi, Atsuko
Yoshimura, Reiji
author_facet Okamoto, Naomichi
Konishi, Yuki
Tesen, Hirofumi
Ikenouchi, Atsuko
Yoshimura, Reiji
author_sort Okamoto, Naomichi
collection PubMed
description Clozapine is recommended for patients with schizophrenia and tardive dystonia (TD); however, the appropriate dose remains unclear. In this case, a low dose (150 mg/day) of clozapine improved refractory TD and further ameliorated psychiatric symptoms. Herein, we report on a 41-year-old female with schizophrenia and TD who was treated with a low clozapine dose. After eight weeks of continuous clozapine at 150 mg/day (16 weeks after clozapine initiation), her TD dramatically improved, and her psychiatric symptoms were relieved. Low clozapine doses could ameliorate refractory TD. However, this effect might require up to several weeks. Clinicians should be patient unless they consider it better to increase the clozapine dose.
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spelling pubmed-80577972021-04-21 A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report Okamoto, Naomichi Konishi, Yuki Tesen, Hirofumi Ikenouchi, Atsuko Yoshimura, Reiji Int Med Case Rep J Case Report Clozapine is recommended for patients with schizophrenia and tardive dystonia (TD); however, the appropriate dose remains unclear. In this case, a low dose (150 mg/day) of clozapine improved refractory TD and further ameliorated psychiatric symptoms. Herein, we report on a 41-year-old female with schizophrenia and TD who was treated with a low clozapine dose. After eight weeks of continuous clozapine at 150 mg/day (16 weeks after clozapine initiation), her TD dramatically improved, and her psychiatric symptoms were relieved. Low clozapine doses could ameliorate refractory TD. However, this effect might require up to several weeks. Clinicians should be patient unless they consider it better to increase the clozapine dose. Dove 2021-04-16 /pmc/articles/PMC8057797/ /pubmed/33889030 http://dx.doi.org/10.2147/IMCRJ.S307410 Text en © 2021 Okamoto et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Okamoto, Naomichi
Konishi, Yuki
Tesen, Hirofumi
Ikenouchi, Atsuko
Yoshimura, Reiji
A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report
title A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report
title_full A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report
title_fullStr A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report
title_full_unstemmed A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report
title_short A Low Clozapine Dose Improved Refractory Tardive Dystonia without Exacerbating Psychiatric Symptoms: A Case Report
title_sort low clozapine dose improved refractory tardive dystonia without exacerbating psychiatric symptoms: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057797/
https://www.ncbi.nlm.nih.gov/pubmed/33889030
http://dx.doi.org/10.2147/IMCRJ.S307410
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