Cargando…
Global epistasis emerges from a generic model of a complex trait
Epistasis between mutations can make adaptation contingent on evolutionary history. Yet despite widespread ‘microscopic’ epistasis between the mutations involved, microbial evolution experiments show consistent patterns of fitness increase between replicate lines. Recent work shows that this consist...
Autores principales: | Reddy, Gautam, Desai, Michael M |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057814/ https://www.ncbi.nlm.nih.gov/pubmed/33779543 http://dx.doi.org/10.7554/eLife.64740 |
Ejemplares similares
-
Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo
por: Taverner, Andrew M, et al.
Publicado: (2019) -
Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast
por: Nguyen Ba, Alex N, et al.
Publicado: (2022) -
A model and test for coordinated polygenic epistasis in complex traits
por: Sheppard, Brooke, et al.
Publicado: (2021) -
On the mechanistic nature of epistasis in a canonical cis-regulatory element
por: Lagator, Mato, et al.
Publicado: (2017) -
Stability-mediated epistasis constrains the evolution of an influenza protein
por: Gong, Lizhi Ian, et al.
Publicado: (2013)