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Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus
Astragalus Radix is one of the common traditional Chinese medicines used to treat diabetes. However, the underlying mechanism is not fully understood. Flavones are a class of active components that have been reported to exert various activities. Existing evidence suggests that flavones from Astragal...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057874/ https://www.ncbi.nlm.nih.gov/pubmed/33953787 http://dx.doi.org/10.1155/2021/6675567 |
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author | Wang, Zhe Li, Xu-Ling Hong, Kin-Fong Zhao, Ting-Ting Dong, Rui-Xue Wang, Wei-Ming Li, Yun-Tong Zhang, Gui-Lin Lin, Jing Gui, Ding-Kun Xu, You-Hua |
author_facet | Wang, Zhe Li, Xu-Ling Hong, Kin-Fong Zhao, Ting-Ting Dong, Rui-Xue Wang, Wei-Ming Li, Yun-Tong Zhang, Gui-Lin Lin, Jing Gui, Ding-Kun Xu, You-Hua |
author_sort | Wang, Zhe |
collection | PubMed |
description | Astragalus Radix is one of the common traditional Chinese medicines used to treat diabetes. However, the underlying mechanism is not fully understood. Flavones are a class of active components that have been reported to exert various activities. Existing evidence suggests that flavones from Astragalus Radix may be pivotal in modulating progression of diabetes. In this study, total flavones from Astragalus Radix (TFA) were studied to observe its effects on metabolism of bile acids both in vivo and in vitro. C57BL/6J mice were treated with STZ and high-fat feeding to construct diabetic model, and HepG2 cell line was applied to investigate the influence of TFA on liver cells. We found a serious disturbance of bile acids and lipid metabolism in diabetic mice, and oral administration or cell incubation with TFA significantly reduced the production of total cholesterol (TCHO), total triglyceride, glutamic oxalacetic transaminase (AST), glutamic-pyruvic transaminase (ALT), and low-density lipoprotein (LDL-C), while it increased the level of high-density lipoprotein (HDL-C). The expression of glucose transporter 2 (GLUT2) and cholesterol 7α-hydroxylase (CYP7A1) was significantly upregulated on TFA treatment, and FXR and TGR5 play pivotal role in modulating bile acid and lipid metabolism. This study supplied a novel understanding towards the mechanism of Astragalus Radix on controlling diabetes. |
format | Online Article Text |
id | pubmed-8057874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80578742021-05-04 Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus Wang, Zhe Li, Xu-Ling Hong, Kin-Fong Zhao, Ting-Ting Dong, Rui-Xue Wang, Wei-Ming Li, Yun-Tong Zhang, Gui-Lin Lin, Jing Gui, Ding-Kun Xu, You-Hua Evid Based Complement Alternat Med Research Article Astragalus Radix is one of the common traditional Chinese medicines used to treat diabetes. However, the underlying mechanism is not fully understood. Flavones are a class of active components that have been reported to exert various activities. Existing evidence suggests that flavones from Astragalus Radix may be pivotal in modulating progression of diabetes. In this study, total flavones from Astragalus Radix (TFA) were studied to observe its effects on metabolism of bile acids both in vivo and in vitro. C57BL/6J mice were treated with STZ and high-fat feeding to construct diabetic model, and HepG2 cell line was applied to investigate the influence of TFA on liver cells. We found a serious disturbance of bile acids and lipid metabolism in diabetic mice, and oral administration or cell incubation with TFA significantly reduced the production of total cholesterol (TCHO), total triglyceride, glutamic oxalacetic transaminase (AST), glutamic-pyruvic transaminase (ALT), and low-density lipoprotein (LDL-C), while it increased the level of high-density lipoprotein (HDL-C). The expression of glucose transporter 2 (GLUT2) and cholesterol 7α-hydroxylase (CYP7A1) was significantly upregulated on TFA treatment, and FXR and TGR5 play pivotal role in modulating bile acid and lipid metabolism. This study supplied a novel understanding towards the mechanism of Astragalus Radix on controlling diabetes. Hindawi 2021-04-12 /pmc/articles/PMC8057874/ /pubmed/33953787 http://dx.doi.org/10.1155/2021/6675567 Text en Copyright © 2021 Zhe Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Zhe Li, Xu-Ling Hong, Kin-Fong Zhao, Ting-Ting Dong, Rui-Xue Wang, Wei-Ming Li, Yun-Tong Zhang, Gui-Lin Lin, Jing Gui, Ding-Kun Xu, You-Hua Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus |
title | Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus |
title_full | Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus |
title_fullStr | Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus |
title_full_unstemmed | Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus |
title_short | Total flavonoids of Astragalus Ameliorated Bile Acid Metabolism Dysfunction in Diabetes Mellitus |
title_sort | total flavonoids of astragalus ameliorated bile acid metabolism dysfunction in diabetes mellitus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057874/ https://www.ncbi.nlm.nih.gov/pubmed/33953787 http://dx.doi.org/10.1155/2021/6675567 |
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