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Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy
This study reports dose corresponding to visible radiation induced liver damage following Stereotactic Body Radiation Therapy (SBRT) for liver metastasis, and the optimal time for follow up scans using post radiation imaging. Diagnostic magnetic resonance scans of nine patients treated with liver SB...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058022/ https://www.ncbi.nlm.nih.gov/pubmed/33898785 http://dx.doi.org/10.1016/j.phro.2021.01.009 |
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author | Yadav, Poonam Kuczmarska-Haas, Aleksandra Musunuru, Hima Bindu Witt, Jacob Blitzer, Grace Mahler, Peter Bassetti, Michael F. |
author_facet | Yadav, Poonam Kuczmarska-Haas, Aleksandra Musunuru, Hima Bindu Witt, Jacob Blitzer, Grace Mahler, Peter Bassetti, Michael F. |
author_sort | Yadav, Poonam |
collection | PubMed |
description | This study reports dose corresponding to visible radiation induced liver damage following Stereotactic Body Radiation Therapy (SBRT) for liver metastasis, and the optimal time for follow up scans using post radiation imaging. Diagnostic magnetic resonance scans of nine patients treated with liver SBRT using a 0.35 T MRI-guided radiotherapy system were analyzed. The dice coefficients between the region of visible liver damage and the delivered dose were calculated. A median dose of 35 Gy correlated most closely with the visible radiation induced liver damage. We compared scans over two to nine months and observed maximal dice coefficients at two to five months post radiation. We have presented a new method for developing treatment planning guidelines for liver SBRT. |
format | Online Article Text |
id | pubmed-8058022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-80580222021-04-23 Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy Yadav, Poonam Kuczmarska-Haas, Aleksandra Musunuru, Hima Bindu Witt, Jacob Blitzer, Grace Mahler, Peter Bassetti, Michael F. Phys Imaging Radiat Oncol Short Communication This study reports dose corresponding to visible radiation induced liver damage following Stereotactic Body Radiation Therapy (SBRT) for liver metastasis, and the optimal time for follow up scans using post radiation imaging. Diagnostic magnetic resonance scans of nine patients treated with liver SBRT using a 0.35 T MRI-guided radiotherapy system were analyzed. The dice coefficients between the region of visible liver damage and the delivered dose were calculated. A median dose of 35 Gy correlated most closely with the visible radiation induced liver damage. We compared scans over two to nine months and observed maximal dice coefficients at two to five months post radiation. We have presented a new method for developing treatment planning guidelines for liver SBRT. Elsevier 2021-02-06 /pmc/articles/PMC8058022/ /pubmed/33898785 http://dx.doi.org/10.1016/j.phro.2021.01.009 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Short Communication Yadav, Poonam Kuczmarska-Haas, Aleksandra Musunuru, Hima Bindu Witt, Jacob Blitzer, Grace Mahler, Peter Bassetti, Michael F. Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy |
title | Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy |
title_full | Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy |
title_fullStr | Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy |
title_full_unstemmed | Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy |
title_short | Evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided Stereotactic Body radiotherapy |
title_sort | evaluating dose constraints for radiation induced liver damage following magnetic resonance image guided stereotactic body radiotherapy |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058022/ https://www.ncbi.nlm.nih.gov/pubmed/33898785 http://dx.doi.org/10.1016/j.phro.2021.01.009 |
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