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Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at (G)γ-globin gene promoter

The reactivation of γ-globin chain synthesis to combine with excess free α-globin chains and form fetal hemoglobin (HbF) is an important alternative treatment for β-thalassemia. We had reported HbF induction property of natural curcuminoids, curcumin (Cur), demethoxycurcumin (DMC) and bis-demethoxyc...

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Detalles Bibliográficos
Autores principales:	Nuamsee, Khanita, Chuprajob, Thipphawan, Pabuprapap, Wachirachai, Jintaridth, Pornrutsami, Munkongdee, Thongperm, Phannasil, Phatchariya, Vadolas, Jim, Chaichompoo, Pornthip, Suksamrarn, Apichart, Svasti, Saovaros
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058333/ https://www.ncbi.nlm.nih.gov/pubmed/33879818 http://dx.doi.org/10.1038/s41598-021-87738-2

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