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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles
Oligonucleotide therapeutics hold promise for the treatment of muscle- and heart-related diseases. However, oligonucleotide delivery across the continuous endothelium of muscle tissue is challenging. Here, we demonstrate that docosanoic acid (DCA) conjugation of small interfering RNAs (siRNAs) enabl...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058398/ https://www.ncbi.nlm.nih.gov/pubmed/33348054 http://dx.doi.org/10.1016/j.ymthe.2020.12.023 |