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Reflexive and Intentional Saccadic Eye Movements in Migraineurs

Background: Migraine has been postulated to lead to structural and functional changes of different cortical and subcortical areas, including the frontal lobe, the brainstem, and cerebellum. The (sub-)clinical impact of these changes is a matter of debate. The spectrum of possible clinical difference...

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Autores principales: Filippopulos, Filipp M., Goeschy, Christine, Schoeberl, Florian, Eren, Ozan E., Straube, Andreas, Eggert, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058404/
https://www.ncbi.nlm.nih.gov/pubmed/33897613
http://dx.doi.org/10.3389/fneur.2021.669922
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author Filippopulos, Filipp M.
Goeschy, Christine
Schoeberl, Florian
Eren, Ozan E.
Straube, Andreas
Eggert, Thomas
author_facet Filippopulos, Filipp M.
Goeschy, Christine
Schoeberl, Florian
Eren, Ozan E.
Straube, Andreas
Eggert, Thomas
author_sort Filippopulos, Filipp M.
collection PubMed
description Background: Migraine has been postulated to lead to structural and functional changes of different cortical and subcortical areas, including the frontal lobe, the brainstem, and cerebellum. The (sub-)clinical impact of these changes is a matter of debate. The spectrum of possible clinical differences include domains such as cognition but also coordination. The present study investigated the oculomotor performance of patients with migraine with and without aura compared to control subjects without migraine in reflexive saccades, but also in intentional saccades, which involve cerebellar as well as cortical networks. Methods: In 18 patients with migraine with aura and 21 patients with migraine without aura saccadic eye movements were recorded in two reflexive (gap, overlap) and two intentional (anti, memory) paradigms and compared to 25 controls without migraine. Results: The main finding of the study was an increase of saccade latency in patients with and without aura compared to the control group solely in the anti-task. No deficits were found in the execution of reflexive saccades. Conclusions: Our results suggest a specific deficit in the generation of correct anti-saccades, such as vector inversion. Such processes are considered to need cortical networks to be executed correctly. The parietal cortex has been suggested to be involved in vector inversion processes but is not commonly described to be altered in migraine patients. It could be discussed that the cerebellum, which is recently thought to be involved in the pathophysiology of migraine, might be involved in distinct processes such as spatial re-mapping through known interconnections with parietal and frontal cortical areas.
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spelling pubmed-80584042021-04-22 Reflexive and Intentional Saccadic Eye Movements in Migraineurs Filippopulos, Filipp M. Goeschy, Christine Schoeberl, Florian Eren, Ozan E. Straube, Andreas Eggert, Thomas Front Neurol Neurology Background: Migraine has been postulated to lead to structural and functional changes of different cortical and subcortical areas, including the frontal lobe, the brainstem, and cerebellum. The (sub-)clinical impact of these changes is a matter of debate. The spectrum of possible clinical differences include domains such as cognition but also coordination. The present study investigated the oculomotor performance of patients with migraine with and without aura compared to control subjects without migraine in reflexive saccades, but also in intentional saccades, which involve cerebellar as well as cortical networks. Methods: In 18 patients with migraine with aura and 21 patients with migraine without aura saccadic eye movements were recorded in two reflexive (gap, overlap) and two intentional (anti, memory) paradigms and compared to 25 controls without migraine. Results: The main finding of the study was an increase of saccade latency in patients with and without aura compared to the control group solely in the anti-task. No deficits were found in the execution of reflexive saccades. Conclusions: Our results suggest a specific deficit in the generation of correct anti-saccades, such as vector inversion. Such processes are considered to need cortical networks to be executed correctly. The parietal cortex has been suggested to be involved in vector inversion processes but is not commonly described to be altered in migraine patients. It could be discussed that the cerebellum, which is recently thought to be involved in the pathophysiology of migraine, might be involved in distinct processes such as spatial re-mapping through known interconnections with parietal and frontal cortical areas. Frontiers Media S.A. 2021-04-07 /pmc/articles/PMC8058404/ /pubmed/33897613 http://dx.doi.org/10.3389/fneur.2021.669922 Text en Copyright © 2021 Filippopulos, Goeschy, Schoeberl, Eren, Straube and Eggert. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Filippopulos, Filipp M.
Goeschy, Christine
Schoeberl, Florian
Eren, Ozan E.
Straube, Andreas
Eggert, Thomas
Reflexive and Intentional Saccadic Eye Movements in Migraineurs
title Reflexive and Intentional Saccadic Eye Movements in Migraineurs
title_full Reflexive and Intentional Saccadic Eye Movements in Migraineurs
title_fullStr Reflexive and Intentional Saccadic Eye Movements in Migraineurs
title_full_unstemmed Reflexive and Intentional Saccadic Eye Movements in Migraineurs
title_short Reflexive and Intentional Saccadic Eye Movements in Migraineurs
title_sort reflexive and intentional saccadic eye movements in migraineurs
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058404/
https://www.ncbi.nlm.nih.gov/pubmed/33897613
http://dx.doi.org/10.3389/fneur.2021.669922
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