Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population

A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relati...

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Autores principales: Fan, Liyuan, Shi, Changhe, Hu, Xinchao, Zhang, Zhongxian, Zheng, Huimin, Luo, Haiyang, Fan, Yu, Zhang, Shuo, Hu, Zhengwei, Yang, Jing, Mao, Chengyuan, Xu, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058430/
https://www.ncbi.nlm.nih.gov/pubmed/33897588
http://dx.doi.org/10.3389/fneur.2021.623913
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author Fan, Liyuan
Shi, Changhe
Hu, Xinchao
Zhang, Zhongxian
Zheng, Huimin
Luo, Haiyang
Fan, Yu
Zhang, Shuo
Hu, Zhengwei
Yang, Jing
Mao, Chengyuan
Xu, Yuming
author_facet Fan, Liyuan
Shi, Changhe
Hu, Xinchao
Zhang, Zhongxian
Zheng, Huimin
Luo, Haiyang
Fan, Yu
Zhang, Shuo
Hu, Zhengwei
Yang, Jing
Mao, Chengyuan
Xu, Yuming
author_sort Fan, Liyuan
collection PubMed
description A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 healthy controls. In the allele model, it was found that rs10748818/GBF1 was associated with PD in the Chinese Han population [p = 0.035, odds ratio (OR) 1.221, 95% confidence interval (CI) 1.014–1.472
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spelling pubmed-80584302021-04-22 Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population Fan, Liyuan Shi, Changhe Hu, Xinchao Zhang, Zhongxian Zheng, Huimin Luo, Haiyang Fan, Yu Zhang, Shuo Hu, Zhengwei Yang, Jing Mao, Chengyuan Xu, Yuming Front Neurol Neurology A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 healthy controls. In the allele model, it was found that rs10748818/GBF1 was associated with PD in the Chinese Han population [p = 0.035, odds ratio (OR) 1.221, 95% confidence interval (CI) 1.014–1.472 Frontiers Media S.A. 2021-04-07 /pmc/articles/PMC8058430/ /pubmed/33897588 http://dx.doi.org/10.3389/fneur.2021.623913 Text en Copyright © 2021 Fan, Shi, Hu, Zhang, Zheng, Luo, Fan, Zhang, Hu, Yang, Mao and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Fan, Liyuan
Shi, Changhe
Hu, Xinchao
Zhang, Zhongxian
Zheng, Huimin
Luo, Haiyang
Fan, Yu
Zhang, Shuo
Hu, Zhengwei
Yang, Jing
Mao, Chengyuan
Xu, Yuming
Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population
title Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population
title_full Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population
title_fullStr Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population
title_full_unstemmed Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population
title_short Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population
title_sort analysis of 12 gwas-linked loci with parkinson’s disease in the chinese han population
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058430/
https://www.ncbi.nlm.nih.gov/pubmed/33897588
http://dx.doi.org/10.3389/fneur.2021.623913
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