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Modeling human retinoblastoma using embryonic stem cell-derived retinal organoids

Retinoblastoma (Rb) is the most prevalent intraocular malignancy in early childhood. Traditional models are unable to accurately recapitulate the origin and development of human Rb. Here, we present a protocol to establish a novel human Rb organoid (hRBO) model derived from genetically engineered hu...

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Detalles Bibliográficos
Autores principales: Liu, Hui, Hua, Zi-Qi, Jin, Zi-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058612/
https://www.ncbi.nlm.nih.gov/pubmed/33899024
http://dx.doi.org/10.1016/j.xpro.2021.100444