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Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report

BACKGROUND: Gastrointestinal cytomegalovirus (CMV) disease occurs commonly in immunocompromised/immunodeficient patients with advanced human immunodeficiency virus infection, neoplasm, solid organ transplantation, hematopoietic stem cell transplantation, or treatment with immunosuppressants, but is...

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Autores principales: Yang, Qing-Hua, Ma, Xiao-Peng, Dai, Dong-Ling, Bai, Da-Ming, Zou, Yu, Liu, Si-Xi, Song, Jian-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058656/
https://www.ncbi.nlm.nih.gov/pubmed/33958850
http://dx.doi.org/10.3748/wjg.v27.i15.1655
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author Yang, Qing-Hua
Ma, Xiao-Peng
Dai, Dong-Ling
Bai, Da-Ming
Zou, Yu
Liu, Si-Xi
Song, Jian-Ming
author_facet Yang, Qing-Hua
Ma, Xiao-Peng
Dai, Dong-Ling
Bai, Da-Ming
Zou, Yu
Liu, Si-Xi
Song, Jian-Ming
author_sort Yang, Qing-Hua
collection PubMed
description BACKGROUND: Gastrointestinal cytomegalovirus (CMV) disease occurs commonly in immunocompromised/immunodeficient patients with advanced human immunodeficiency virus infection, neoplasm, solid organ transplantation, hematopoietic stem cell transplantation, or treatment with immunosuppressants, but is rarely reported in association with measles infection. CASE SUMMARY: We describe a case of extensive gastrointestinal CMV disease secondary to measles infection in a 9-mo-old boy who presented with persistent fever and bloody diarrhea. His condition was improved after ganciclovir treatment. Serological analysis of CMV showed negative immunoglobulin (Ig) M and positive IgG. Blood CMV-DNA was 9.26 × 10(3) copies/mL. The diagnosis of gastrointestinal CMV disease was confirmed by histopathological findings of intranuclear and intracytoplasmic inclusions and Owl’s eye inclusion. This case highlights the differential diagnosis and histopathological characteristics of gastrointestinal CMV infection and laboratory tests. CONCLUSION: Extensive gastrointestinal CMV lesions can be induced by the immune suppression secondary to measles infection. Rational, fast, and effective laboratory examinations are essential for suspected patients.
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spelling pubmed-80586562021-05-05 Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report Yang, Qing-Hua Ma, Xiao-Peng Dai, Dong-Ling Bai, Da-Ming Zou, Yu Liu, Si-Xi Song, Jian-Ming World J Gastroenterol Case Report BACKGROUND: Gastrointestinal cytomegalovirus (CMV) disease occurs commonly in immunocompromised/immunodeficient patients with advanced human immunodeficiency virus infection, neoplasm, solid organ transplantation, hematopoietic stem cell transplantation, or treatment with immunosuppressants, but is rarely reported in association with measles infection. CASE SUMMARY: We describe a case of extensive gastrointestinal CMV disease secondary to measles infection in a 9-mo-old boy who presented with persistent fever and bloody diarrhea. His condition was improved after ganciclovir treatment. Serological analysis of CMV showed negative immunoglobulin (Ig) M and positive IgG. Blood CMV-DNA was 9.26 × 10(3) copies/mL. The diagnosis of gastrointestinal CMV disease was confirmed by histopathological findings of intranuclear and intracytoplasmic inclusions and Owl’s eye inclusion. This case highlights the differential diagnosis and histopathological characteristics of gastrointestinal CMV infection and laboratory tests. CONCLUSION: Extensive gastrointestinal CMV lesions can be induced by the immune suppression secondary to measles infection. Rational, fast, and effective laboratory examinations are essential for suspected patients. Baishideng Publishing Group Inc 2021-04-21 2021-04-21 /pmc/articles/PMC8058656/ /pubmed/33958850 http://dx.doi.org/10.3748/wjg.v27.i15.1655 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Case Report
Yang, Qing-Hua
Ma, Xiao-Peng
Dai, Dong-Ling
Bai, Da-Ming
Zou, Yu
Liu, Si-Xi
Song, Jian-Ming
Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
title Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
title_full Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
title_fullStr Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
title_full_unstemmed Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
title_short Gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: A case report
title_sort gastrointestinal cytomegalovirus disease secondary to measles in an immunocompetent infant: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058656/
https://www.ncbi.nlm.nih.gov/pubmed/33958850
http://dx.doi.org/10.3748/wjg.v27.i15.1655
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