Cargando…

Radiation-induced abscopal reproductive effect is driven by TNF-α/p38 MAPK/Rac1 axis in Sertoli cells

Rationale: Radiotherapy has become a mainstay for tumor management, and more than 50% of patients with thoracic tumor need to be treated with radiotherapy. However, the potential adverse effects of thoracic radiotherapy on the reproductive system remain elusive. Methods: Western blot analysis, immun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Songling, Zhu, Lin, Song, Yimeng, Zhao, Xinrui, Chen, Qianping, Pan, Yan, Zhang, Jianghong, Bai, Yang, Zhang, Haowen, Shao, Chunlin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058717/ https://www.ncbi.nlm.nih.gov/pubmed/33897879 http://dx.doi.org/10.7150/thno.56853

Ejemplares similares

Fractionated Irradiation of Right Thorax Induces Abscopal Damage on Bone Marrow Cells via TNF-α and SAA
por: Song, Yimeng, et al.
Publicado: (2021)

Macrophage contributes to radiation-induced anti-tumor abscopal effect on transplanted breast cancer by HMGB1/TNF-α signaling factors
por: Zhu, Lin, et al.
Publicado: (2021)

Irradiation combined with PD-L1(−/−) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation
por: Zhao, Xinrui, et al.
Publicado: (2022)

Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility
por: Zhang, Junling, et al.
Publicado: (2019)

Radiotherapy-Mediated Immunomodulation and Anti-Tumor Abscopal Effect Combining Immune Checkpoint Blockade
por: Zhao, Xinrui, et al.
Publicado: (2020)

ANXA6 Contributes to Radioresistance by Promoting Autophagy via Inhibiting the PI3K/AKT/mTOR Signaling Pathway in Nasopharyngeal Carcinoma
por: Chen, Qianping, et al.
Publicado: (2020)

Galectin-1 enhances TNFα-induced inflammatory responses in Sertoli cells through activation of MAPK signalling
por: Lei, Tao, et al.
Publicado: (2018)

MMP14 Contributes to HDAC Inhibition-Induced Radiosensitization of Glioblastoma
por: Zhou, Yuchuan, et al.
Publicado: (2021)

CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51
por: Zheng, Wang, et al.
Publicado: (2021)

circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway
por: Bian, Qiao, et al.
Publicado: (2021)

GDF15 Contributes to Radioresistance by Mediating the EMT and Stemness of Breast Cancer Cells
por: Zhao, Xinrui, et al.
Publicado: (2022)

TIGAR/AP-1 axis accelerates the division of Lgr5(−) reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation
por: Chen, Fei, et al.
Publicado: (2020)

Rac3 Regulates Cell Invasion, Migration and EMT in Lung Adenocarcinoma through p38 MAPK Pathway
por: Zhang, Chenlei, et al.
Publicado: (2017)

LncRNA CASC19 Enhances the Radioresistance of Nasopharyngeal Carcinoma by Regulating the miR-340-3p/FKBP5 Axis
por: Liu, Hongxia, et al.
Publicado: (2023)

Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment
por: Zhang, Yuhong, et al.
Publicado: (2022)

SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma
por: Chen, Qianping, et al.
Publicado: (2022)

Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis
por: Heinrich, Anna, et al.
Publicado: (2020)

FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation
por: Dibus, Nikol, et al.
Publicado: (2022)

Regulation of myogenic activation of p38 MAPK by TACE-mediated TNFα release
por: Li, Yi-Ping, et al.
Publicado: (2014)

TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK
por: Ni, Yawen, et al.
Publicado: (2017)

A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion
por: Hetmanski, Joseph H. R., et al.
Publicado: (2016)

Autophagy in inflammation: the p38α MAPK-ULK1 axis
por: She, Hua, et al.
Publicado: (2018)

Cathepsin C Interacts with TNF-α/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma
por: Zhang, Guo-Pei, et al.
Publicado: (2020)

Cyclosporin-A reduced the cytotoxicity of propranolol in HUVECs via p38 MAPK signaling
por: Lv, Zhong, et al.
Publicado: (2022)

Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity
por: Barker, Katie H., et al.
Publicado: (2022)

Infiltrating macrophages in diabetic nephropathy promote podocytes apoptosis via TNF-α-ROS-p38MAPK pathway
por: Guo, Yinfeng, et al.
Publicado: (2017)

Nivolumab and Hypofractionated Radiotherapy in Patients With Advanced Lung Cancer: ABSCOPAL-1 Clinical Trial
por: Ye, Hua, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Chromenylurea and Chromanylurea Derivatives as Anti-TNF-α agents that Target the p38 MAPK Pathway
por: Li, Xingzhou, et al.
Publicado: (2014)

Abscopal effect in the radio and immunotherapy
por: Pevzner, Alina M., et al.
Publicado: (2021)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

UVB-Stimulated TNFα Release from Human Melanocyte and Melanoma Cells Is Mediated by p38 MAPK
por: Muthusamy, Visalini, et al.
Publicado: (2013)

Research Progress and Existing Problems for Abscopal Effect
por: Wang, Di, et al.
Publicado: (2020)

Involvement of p38-βTrCP-Tristetraprolin-TNFα axis in radiation pneumonitis
por: Krishnamurthy, Pranathi Meda, et al.
Publicado: (2017)

Mechanism of oxidative stress p38MAPK-SGK1 signaling axis in experimental autoimmune encephalomyelitis (EAE)
por: Wang, Liang, et al.
Publicado: (2017)

Glucocorticoids Regulate the Vascular Remodeling of Aortic Dissection Via the p38 MAPK-HSP27 Pathway Mediated by Soluble TNF-RII
por: Zhang, Lei, et al.
Publicado: (2017)

The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway
por: Chen, Yanqing, et al.
Publicado: (2022)

Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-α secretion and apoptosis
por: Nagila, Amar, et al.
Publicado: (2013)

Comment on “Abscopal effect in the radio and immunotherapy”
por: Fabi, François
Publicado: (2022)

The Abscopal Effect in the Era of Checkpoint Inhibitors
por: Kodet, Ondřej, et al.
Publicado: (2021)

Electroporation and Immunotherapy—Unleashing the Abscopal Effect
por: Justesen, Tobias Freyberg, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3r160p5djv8mt1nmupjkk8ksra