Repurposing (18)F-FMISO as a PET tracer for translational imaging of nitroreductase-based gene directed enzyme prodrug therapy

Nitroreductases (NTR) are a family of bacterial enzymes used in gene directed enzyme prodrug therapy (GDEPT) that selectively activate prodrugs containing aromatic nitro groups to exert cytotoxic effects following gene transduction in tumours. The clinical development of NTR-based GDEPT has, in part...

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Detalles Bibliográficos
Autores principales: Ruiz de Garibay, Gorka, García de Jalón, Elvira, Stigen, Endre, Lund, Kjetil B, Popa, Mihaela, Davidson, Ben, Safont, Mireia Mayoral, Rygh, Cecilie B., Espedal, Heidi, Barrett, Torill M, Haug, Bengt Erik, McCormack, Emmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058731/
https://www.ncbi.nlm.nih.gov/pubmed/33897898
http://dx.doi.org/10.7150/thno.55092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058731/
https://www.ncbi.nlm.nih.gov/pubmed/33897898
http://dx.doi.org/10.7150/thno.55092

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