A pain killer without analgesic tolerance designed by co-targeting PSD-95-nNOS interaction and α2-containning GABA(A)Rs

Overactivation of N-methyl-D-aspartate receptor (NMDAR) in the spinal cord dorsal horn (SDH) in the setting of injury represents a key mechanism of neuropathic pain. However, directly blocking NMDAR or its downstream signaling, interaction between postsynaptic density-95 (PSD-95) and neuronal nitric...

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Detalles Bibliográficos
Autores principales: Li, Jun, Zhang, Lin, Xu, Chu, Shen, Ying-Ying, Lin, Yu-Hui, Zhang, Yu, Wu, Hai-Yin, Chang, Lei, Zhang, Ying-Dong, Chen, Rong, Zhang, Zheng-Ping, Luo, Chun-Xia, Li, Fei, Zhu, Dong-Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8058733/
https://www.ncbi.nlm.nih.gov/pubmed/33897893
http://dx.doi.org/10.7150/thno.58364

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