Cargando…

Combined treatment of Taraxaci Herba and R7050 alleviates the symptoms of herpes simplex virus-induced Behçet's disease in rats

BACKGROUND: Behçet's disease (BD) is a chronic inflammatory systemic disease that affects multiple organs. The causes of BD are still unknown, but it is primarily characterized by autoimmune reaction in the blood vessels. Current research focuses on treatments that can reduce the non-typical in...

Descripción completa

Detalles Bibliográficos
Autores principales: Cha, Myeounghoon, Kwon, Minjee, Park, Misun, Oh, Jin-Hwan, Sung, Kang-Keyng, Lee, Bae Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059053/
https://www.ncbi.nlm.nih.gov/pubmed/33898245
http://dx.doi.org/10.1016/j.imr.2021.100720
_version_ 1783681133216530432
author Cha, Myeounghoon
Kwon, Minjee
Park, Misun
Oh, Jin-Hwan
Sung, Kang-Keyng
Lee, Bae Hwan
author_facet Cha, Myeounghoon
Kwon, Minjee
Park, Misun
Oh, Jin-Hwan
Sung, Kang-Keyng
Lee, Bae Hwan
author_sort Cha, Myeounghoon
collection PubMed
description BACKGROUND: Behçet's disease (BD) is a chronic inflammatory systemic disease that affects multiple organs. The causes of BD are still unknown, but it is primarily characterized by autoimmune reaction in the blood vessels. Current research focuses on treatments that can reduce the non-typical inflammatory responses of BD. Nevertheless, studies on improving the inflammatory effect of BD using inflammation mechanisms are still insufficient. Therefore, we conducted the integrated treatments related to inflammation modulation and achieved alleviation of symptoms in BD mice. METHODS: To understand the complex etiology of BD and compare its management, the herpes simplex virus (HSV)-induced BD mouse model was used. In order to alleviate the inflammatory response in BD mice, Taraxaci Herba (TH, herbal medicine), R7050-a TNFα inhibitor, and a mixture of TH and R7050 were injected for 2 weeks repetitively. The SCORAD index was examined to evaluate the cutaneous inflammations. In addition, histological changes and inflammatory factors were analyzed. RESULTS: Repetitive injection of TH and/or R7050 reduced the symptoms of BD and significantly decreased IL-6, IL-1β, and TNFα in blood sera. Moreover, this treatment reduced the ulcers and the deterioration of skin. CONCLUSIONS: The results of our study showed that the down-regulation of inflammatory factors is related to the control of immune responses in BD models, suggesting that a mixed drug treatment may be more effective in improving the condition of BD.
format Online
Article
Text
id pubmed-8059053
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-80590532021-04-23 Combined treatment of Taraxaci Herba and R7050 alleviates the symptoms of herpes simplex virus-induced Behçet's disease in rats Cha, Myeounghoon Kwon, Minjee Park, Misun Oh, Jin-Hwan Sung, Kang-Keyng Lee, Bae Hwan Integr Med Res Original Article BACKGROUND: Behçet's disease (BD) is a chronic inflammatory systemic disease that affects multiple organs. The causes of BD are still unknown, but it is primarily characterized by autoimmune reaction in the blood vessels. Current research focuses on treatments that can reduce the non-typical inflammatory responses of BD. Nevertheless, studies on improving the inflammatory effect of BD using inflammation mechanisms are still insufficient. Therefore, we conducted the integrated treatments related to inflammation modulation and achieved alleviation of symptoms in BD mice. METHODS: To understand the complex etiology of BD and compare its management, the herpes simplex virus (HSV)-induced BD mouse model was used. In order to alleviate the inflammatory response in BD mice, Taraxaci Herba (TH, herbal medicine), R7050-a TNFα inhibitor, and a mixture of TH and R7050 were injected for 2 weeks repetitively. The SCORAD index was examined to evaluate the cutaneous inflammations. In addition, histological changes and inflammatory factors were analyzed. RESULTS: Repetitive injection of TH and/or R7050 reduced the symptoms of BD and significantly decreased IL-6, IL-1β, and TNFα in blood sera. Moreover, this treatment reduced the ulcers and the deterioration of skin. CONCLUSIONS: The results of our study showed that the down-regulation of inflammatory factors is related to the control of immune responses in BD models, suggesting that a mixed drug treatment may be more effective in improving the condition of BD. Elsevier 2021-09 2021-02-17 /pmc/articles/PMC8059053/ /pubmed/33898245 http://dx.doi.org/10.1016/j.imr.2021.100720 Text en © 2021 Published by Elsevier B.V. on behalf of Korea Institute of Oriental Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Cha, Myeounghoon
Kwon, Minjee
Park, Misun
Oh, Jin-Hwan
Sung, Kang-Keyng
Lee, Bae Hwan
Combined treatment of Taraxaci Herba and R7050 alleviates the symptoms of herpes simplex virus-induced Behçet's disease in rats
title Combined treatment of Taraxaci Herba and R7050 alleviates the symptoms of herpes simplex virus-induced Behçet's disease in rats
title_full Combined treatment of Taraxaci Herba and R7050 alleviates the symptoms of herpes simplex virus-induced Behçet's disease in rats
title_fullStr Combined treatment of Taraxaci Herba and R7050 alleviates the symptoms of herpes simplex virus-induced Behçet's disease in rats
title_full_unstemmed Combined treatment of Taraxaci Herba and R7050 alleviates the symptoms of herpes simplex virus-induced Behçet's disease in rats
title_short Combined treatment of Taraxaci Herba and R7050 alleviates the symptoms of herpes simplex virus-induced Behçet's disease in rats
title_sort combined treatment of taraxaci herba and r7050 alleviates the symptoms of herpes simplex virus-induced behçet's disease in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059053/
https://www.ncbi.nlm.nih.gov/pubmed/33898245
http://dx.doi.org/10.1016/j.imr.2021.100720
work_keys_str_mv AT chamyeounghoon combinedtreatmentoftaraxaciherbaandr7050alleviatesthesymptomsofherpessimplexvirusinducedbehcetsdiseaseinrats
AT kwonminjee combinedtreatmentoftaraxaciherbaandr7050alleviatesthesymptomsofherpessimplexvirusinducedbehcetsdiseaseinrats
AT parkmisun combinedtreatmentoftaraxaciherbaandr7050alleviatesthesymptomsofherpessimplexvirusinducedbehcetsdiseaseinrats
AT ohjinhwan combinedtreatmentoftaraxaciherbaandr7050alleviatesthesymptomsofherpessimplexvirusinducedbehcetsdiseaseinrats
AT sungkangkeyng combinedtreatmentoftaraxaciherbaandr7050alleviatesthesymptomsofherpessimplexvirusinducedbehcetsdiseaseinrats
AT leebaehwan combinedtreatmentoftaraxaciherbaandr7050alleviatesthesymptomsofherpessimplexvirusinducedbehcetsdiseaseinrats