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Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells

Fatal familial insomnia (FFI), genetic Creutzfeldt–Jakob disease (gCJD), and Gerstmann–Sträussler–Scheinker (GSS) syndrome are neurodegenerative disorders linked to prion protein (PrP) mutations. The pathogenic mechanisms are not known, but increasing evidence points to mutant PrP misfolding and ret...

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Detalles Bibliográficos
Autores principales:	Restelli, Elena, Capone, Vanessa, Pozzoli, Manuela, Ortolan, Davide, Quaglio, Elena, Corbelli, Alessandro, Fiordaliso, Fabio, Beznoussenko, Galina V., Artuso, Vladimiro, Roiter, Ignazio, Sallese, Michele, Chiesa, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059059/ https://www.ncbi.nlm.nih.gov/pubmed/33662396 http://dx.doi.org/10.1016/j.jbc.2021.100490

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