Cargando…

Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model

Mitochondrial dysfunction underlying metabolic disorders such as obesity and diabetes mellitus is strongly associated with cardiac arrhythmias. Murine Pgc-1α(−/−) hearts replicate disrupted mitochondrial function and model the associated pro-arrhythmic electrophysiological abnormalities. Quantitativ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saadeh, Khalil, Chadda, Karan R., Ahmad, Shiraz, Valli, Haseeb, Nanthakumar, Nakulan, Fazmin, Ibrahim T., Edling, Charlotte E., Huang, Christopher L.-H., Jeevaratnam, Kamalan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059080/ https://www.ncbi.nlm.nih.gov/pubmed/33898262 http://dx.doi.org/10.1016/j.ymgmr.2021.100753

Ejemplares similares

Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor γ co-activator deficient hearts modelling mitochondrial dysfunction
por: Edling, Charlotte E., et al.
Publicado: (2019)

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1β Deficient Murine Hearts
por: Edling, Charlotte E., et al.
Publicado: (2019)

Ageing in Pgc-1β(−/−) mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology
por: Edling, Charlotte E., et al.
Publicado: (2019)

Gene and Protein Expression Profile of Selected Molecular Targets Mediating Electrophysiological Function in Pgc-1α Deficient Murine Atria
por: Chadda, Karan R., et al.
Publicado: (2018)

Anti‐malarial drugs: Mechanisms underlying their proarrhythmic effects
por: Saadeh, Khalil, et al.
Publicado: (2022)

Effects of ageing on pro-arrhythmic ventricular phenotypes in incrementally paced murine Pgc-1β(−/−) hearts
por: Ahmad, Shiraz, et al.
Publicado: (2017)

Ventricular pro-arrhythmic phenotype, arrhythmic substrate, ageing and mitochondrial dysfunction in peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β(−/−)) murine hearts
por: Ahmad, Shiraz, et al.
Publicado: (2018)

Systematic review of renal denervation for the management of cardiac arrhythmias
por: Nantha Kumar, Nakulan, et al.
Publicado: (2021)

Age-dependent atrial arrhythmic phenotype secondary to mitochondrial dysfunction in Pgc-1β deficient murine hearts
por: Valli, Haseeb, et al.
Publicado: (2017)

Reduced cardiomyocyte Na(+) current in the age‐dependent murine Pgc‐1β (−/−) model of ventricular arrhythmia
por: Ahmad, Shiraz, et al.
Publicado: (2018)

Pro‐arrhythmic atrial phenotypes in incrementally paced murine Pgc1β (−/−) hearts: effects of age
por: Valli, Haseeb, et al.
Publicado: (2017)

Age‐dependent electrocardiographic changes in Pgc‐1β deficient murine hearts
por: Ahmad, Shiraz, et al.
Publicado: (2017)

Cardiomyocyte ionic currents in intact young and aged murine Pgc-1β(−/−) atrial preparations
por: Valli, Haseeb, et al.
Publicado: (2018)

Circulating microRNA as a Biomarker for Coronary Artery Disease
por: Fazmin, Ibrahim T., et al.
Publicado: (2020)

Ion channels, long QT syndrome and arrhythmogenesis in ageing
por: Jeevaratnam, Kamalan, et al.
Publicado: (2017)

The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3
por: Chadda, Karan R., et al.
Publicado: (2017)

Cardiac ion channel expression in the equine model ‐ In‐silico prediction utilising RNA sequencing data from mixed tissue samples
por: Premont, Antoine, et al.
Publicado: (2022)

Transcriptional profiles of genes related to electrophysiological function in Scn5a (+/−) murine hearts
por: Takla, Michael, et al.
Publicado: (2021)

Epac‐induced ryanodine receptor type 2 activation inhibits sodium currents in atrial and ventricular murine cardiomyocytes
por: Valli, Haseeb, et al.
Publicado: (2017)

Framing Heartaches: The Cardiac ECM and the Effects of Age
por: Ringström, Nathalie, et al.
Publicado: (2023)

Sodium current inhibition following stimulation of exchange protein directly activated by cyclic-3′,5′-adenosine monophosphate (Epac) in murine skeletal muscle
por: Matthews, Hugh R., et al.
Publicado: (2019)

Clinical and Non-Clinical Cardiovascular Disease Associated Pathologies in Parkinson’s Disease
por: Lee, Bonn, et al.
Publicado: (2023)

Sodium channel biophysics, late sodium current and genetic arrhythmic syndromes
por: Chadda, Karan R., et al.
Publicado: (2017)

Cardiac Potassium Channels: Physiological Insights for Targeted Therapy
por: Jeevaratnam, Kamalan, et al.
Publicado: (2017)

Long COVID-19 and Postural Orthostatic Tachycardia Syndrome- Is Dysautonomia to Be Blamed?
por: Chadda, Karan R., et al.
Publicado: (2022)

Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts
por: Zhang, Yanmin, et al.
Publicado: (2011)

The RyR2-P2328S mutation downregulates Na(v)1.5 producing arrhythmic substrate in murine ventricles
por: Ning, Feifei, et al.
Publicado: (2015)

Mitochondrial Dysfunction Increases Arrhythmic Triggers and Substrates; Potential Anti-arrhythmic Pharmacological Targets
por: Saadeh, Khalil, et al.
Publicado: (2021)

Student perspectives of preparedness characteristics for clinical learning within a fully distributed veterinary teaching model
por: Saadeh, Khalil, et al.
Publicado: (2021)

Cardiac electrophysiological adaptations in the equine athlete—Restitution analysis of electrocardiographic features
por: Li, Mengye, et al.
Publicado: (2018)

Arrhythmogenic Mechanisms in Hypokalaemia: Insights From Pre-clinical Models
por: Tse, Gary, et al.
Publicado: (2021)

Left Ventricular Dysfunction in Arrhythmogenic Cardiomyopathy: Association With Exercise Exposure, Genetic Basis, and Prognosis
por: Lie, Øyvind H., et al.
Publicado: (2021)

Arrhythmogenic right ventricular cardiomyopathy
por: Cho, Yongkeun
Publicado: (2018)

Arrhythmogenic left ventricular cardiomyopathy
por: Mirmomen, Seyedeh Mojdeh, et al.
Publicado: (2020)

Arrhythmogenic left ventricular cardiomyopathy
por: Corrado, Domenico, et al.
Publicado: (2022)

Arrhythmogenic Right Ventricular Cardiomyopathy
por: Dolkar, Tsering, et al.
Publicado: (2022)

Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Dysplasia
por: Francis, Johnson, et al.
Publicado: (2016)

Chloroquine, hydroxychloroquine, and COVID-19: Systematic review and narrative synthesis of efficacy and safety
por: Takla, Michael, et al.
Publicado: (2020)

Arrhythmic risk prediction in arrhythmogenic right ventricular cardiomyopathy: external validation of the arrhythmogenic right ventricular cardiomyopathy risk calculator( )
por: Jordà, Paloma, et al.
Publicado: (2022)

Arrhythmogenic right ventricular cardiomyopathy/dysplasia on the basis of the revised diagnostic criteria in affected families with desmosomal mutations
por: Protonotarios, Nikos, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_67merb6om6rfh6929geplqcrkv