Investigation of the relationship between inherited thrombophilia and novel coronavirus pneumonia

Aim: This study aimed to investigate the relationship between severe novel coronavirus pneumonia (NCP) and hypercoagulable conditions that predispose patients to thrombosis such as the prothrombin gene (F2) rs1799963 (G20210A), factor V Leiden (F5) rs6025 (G1691A) and PAI-1 (rs1799768). Patients: NC...

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Detalles Bibliográficos
Autores principales: Kiraz, Aslihan, Guzeldag, Seda, Eren, Esma, Goksu, Musa, Bayram, Arslan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059147/
http://dx.doi.org/10.2217/fvl-2020-0395
Descripción
Sumario:Aim: This study aimed to investigate the relationship between severe novel coronavirus pneumonia (NCP) and hypercoagulable conditions that predispose patients to thrombosis such as the prothrombin gene (F2) rs1799963 (G20210A), factor V Leiden (F5) rs6025 (G1691A) and PAI-1 (rs1799768). Patients: NCP-diagnosed 62 previously healthy patients were enrolled for the investigation of the thrombophilia-related polymorphisms. Materials & methods: The frequency of genotypes were compared with healthy control group frequencies from other studies. Results: There were no statistically significant differences between the severe patient group and the healthy population regarding the investigated single nucleotide polymorphisms (SNPs). Conclusion: This study is the first to rule out the relationship of rs1799963, rs6025 and rs1799768 with severe NCP.

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