The Effect of Sargassum glaucescens from the Persian Gulf on Neuropathy Pain Induced by Paclitaxel in Mice

BACKGROUND: Marine seaweeds are a famous type of traditional food containing various kinds of secondary metabolites. These organisms have different biological activities such as antitumor, antiviral, and antioxidant. The aim of this study was to investigate the effects of total extract of Sargassum glaucescens on neuropathy pain induced by paclitaxel in mice. MATERIALS AND METHODS: S. glaucescens was collected from the Persian Gulf. The seaweed was extracted by maceration with methanol-ethyl acetate (1:1) solvent. The effect of the extract on neuropathy pain induced by paclitaxel was analyzed. All results were analyzed by one-way analysis of variance. RESULTS: Acute administration of S. glaucescens extract (100 and 200 mg/kg intraperitoneally [i.p.]) 30 min before the test on the 11(th) day significantly reduced the duration of paw licking (P < 0.001). CONCLUSIONS: Chronic treatment with S. glaucescens extract (100, 150, and 200 mg/kg i.p.) from the 6(th) day until the 10(th) day reduced the duration of paw licking. Therefore, S. glaucescens should be considered for further treatment of neuropathy.