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From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of a new viral respiratory infection. It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional...

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Autores principales: Ahmadi Badi, Sara, Tarashi, Samira, Fateh, Abolfazl, Rohani, Pejman, Masotti, Andrea, Siadat, Seyed Davar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059477/
https://www.ncbi.nlm.nih.gov/pubmed/33953641
http://dx.doi.org/10.1155/2021/6611222
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author Ahmadi Badi, Sara
Tarashi, Samira
Fateh, Abolfazl
Rohani, Pejman
Masotti, Andrea
Siadat, Seyed Davar
author_facet Ahmadi Badi, Sara
Tarashi, Samira
Fateh, Abolfazl
Rohani, Pejman
Masotti, Andrea
Siadat, Seyed Davar
author_sort Ahmadi Badi, Sara
collection PubMed
description Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of a new viral respiratory infection. It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional cross-talk, known as the “gut-lung axis.” The effects of microbiota on antiviral immune responses, including dendritic cell (DC) function and lymphocyte homing in the gut-lung axis, have been reported in the recent literature. Additionally, the gut microbiota composition affects (and is affected by) the expression of angiotensin-converting enzyme-2 (ACE2), which is the main receptor for SARS-CoV-2 and contributes to regulate inflammation. Several studies demonstrated an altered microbiota composition in patients infected with SARS-CoV-2, compared to healthy individuals. Furthermore, it has been shown that vaccine efficacy against viral respiratory infection is influenced by probiotics pretreatment. Therefore, the importance of the gut microbiota composition in the lung immune system and ACE2 expression could be valuable to provide optimal therapeutic approaches for SARS-CoV-2 and to preserve the symbiotic relationship of the microbiota with the host.
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spelling pubmed-80594772021-05-04 From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis Ahmadi Badi, Sara Tarashi, Samira Fateh, Abolfazl Rohani, Pejman Masotti, Andrea Siadat, Seyed Davar Mediators Inflamm Review Article Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the outbreak of a new viral respiratory infection. It has been demonstrated that the microbiota has a crucial role in establishing immune responses against respiratory infections, which are controlled by a bidirectional cross-talk, known as the “gut-lung axis.” The effects of microbiota on antiviral immune responses, including dendritic cell (DC) function and lymphocyte homing in the gut-lung axis, have been reported in the recent literature. Additionally, the gut microbiota composition affects (and is affected by) the expression of angiotensin-converting enzyme-2 (ACE2), which is the main receptor for SARS-CoV-2 and contributes to regulate inflammation. Several studies demonstrated an altered microbiota composition in patients infected with SARS-CoV-2, compared to healthy individuals. Furthermore, it has been shown that vaccine efficacy against viral respiratory infection is influenced by probiotics pretreatment. Therefore, the importance of the gut microbiota composition in the lung immune system and ACE2 expression could be valuable to provide optimal therapeutic approaches for SARS-CoV-2 and to preserve the symbiotic relationship of the microbiota with the host. Hindawi 2021-04-16 /pmc/articles/PMC8059477/ /pubmed/33953641 http://dx.doi.org/10.1155/2021/6611222 Text en Copyright © 2021 Sara Ahmadi Badi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ahmadi Badi, Sara
Tarashi, Samira
Fateh, Abolfazl
Rohani, Pejman
Masotti, Andrea
Siadat, Seyed Davar
From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis
title From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis
title_full From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis
title_fullStr From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis
title_full_unstemmed From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis
title_short From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis
title_sort from the role of microbiota in gut-lung axis to sars-cov-2 pathogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059477/
https://www.ncbi.nlm.nih.gov/pubmed/33953641
http://dx.doi.org/10.1155/2021/6611222
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