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The roles of T cell competition and stochastic extinction events in chimeric antigen receptor T cell therapy

Chimeric antigen receptor (CAR) T cell therapy is a remarkably effective immunotherapy that relies on in vivo expansion of engineered CAR T cells, after lymphodepletion (LD) by chemotherapy. The quantitative laws underlying this expansion and subsequent tumour eradication remain unknown. We develop...

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Detalles Bibliográficos
Autores principales:	Kimmel, Gregory J., Locke, Frederick L., Altrock, Philipp M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2021
Materias:	Ecology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059581/ https://www.ncbi.nlm.nih.gov/pubmed/33757357 http://dx.doi.org/10.1098/rspb.2021.0229

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