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Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population

BACKGROUND: The aim of our study was to estimate the association of ficolin‐1 (FCN1) gene (rs10120023, rs1071583) and ficolin‐3 (FCN3) gene (rs3813800, rs10794501) polymorphisms and pulmonary tuberculosis (PTB) susceptibility, as well as their several clinical features, in a Chinese population. METH...

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Autores principales: Li, Ye, You, En‐Qing, Lin, Wen‐Hong, Liu, Xiao‐Ning, Shen, De‐Pei, Zhang, Xin‐Li, Ma, Dong‐Chun, Li, Hong‐Miao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059754/
https://www.ncbi.nlm.nih.gov/pubmed/33591573
http://dx.doi.org/10.1002/jcla.23732
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author Li, Ye
You, En‐Qing
Lin, Wen‐Hong
Liu, Xiao‐Ning
Shen, De‐Pei
Zhang, Xin‐Li
Ma, Dong‐Chun
Li, Hong‐Miao
author_facet Li, Ye
You, En‐Qing
Lin, Wen‐Hong
Liu, Xiao‐Ning
Shen, De‐Pei
Zhang, Xin‐Li
Ma, Dong‐Chun
Li, Hong‐Miao
author_sort Li, Ye
collection PubMed
description BACKGROUND: The aim of our study was to estimate the association of ficolin‐1 (FCN1) gene (rs10120023, rs1071583) and ficolin‐3 (FCN3) gene (rs3813800, rs10794501) polymorphisms and pulmonary tuberculosis (PTB) susceptibility, as well as their several clinical features, in a Chinese population. METHODS: This study included a cohort of 489 PTB patients and 489 healthy controls, and the four SNPs were genotyped by improved multiple ligase detection reaction (iMLDR). RESULTS: We found that there were no significant differences regarding the allele and genotype frequencies of FCN1 rs10120023, rs1071583 and FCN3 rs3813800, rs10794501 between PTB patients and healthy controls (all p > 0.05). The association of three main haplotypes (CC, CT, and TC) in FCN1 and three main haplotypes (CT, GA, and GT) in FCN3 with PTB susceptibility was also analyzed, and no significant association was detected (all p > 0.05). In FCN1, the rs1071583 TT genotype was significantly associated with the occurrence of drug resistance in PTB patients (p = 0.040). In addition, the GG genotype and G allele frequencies of rs3813800 in FCN3 gene were significantly higher in PTB patients with pulmonary infection (p = 0.027, p = 0.020, respectively). CONCLUSIONS: FCN1 and FCN3 genetic variation were not contributed to the pathogenesis of PTB in Chinese. While rs1071583 and rs3813800 variant might associate with several clinical characteristics of PTB.
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spelling pubmed-80597542021-04-23 Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population Li, Ye You, En‐Qing Lin, Wen‐Hong Liu, Xiao‐Ning Shen, De‐Pei Zhang, Xin‐Li Ma, Dong‐Chun Li, Hong‐Miao J Clin Lab Anal Research Articles BACKGROUND: The aim of our study was to estimate the association of ficolin‐1 (FCN1) gene (rs10120023, rs1071583) and ficolin‐3 (FCN3) gene (rs3813800, rs10794501) polymorphisms and pulmonary tuberculosis (PTB) susceptibility, as well as their several clinical features, in a Chinese population. METHODS: This study included a cohort of 489 PTB patients and 489 healthy controls, and the four SNPs were genotyped by improved multiple ligase detection reaction (iMLDR). RESULTS: We found that there were no significant differences regarding the allele and genotype frequencies of FCN1 rs10120023, rs1071583 and FCN3 rs3813800, rs10794501 between PTB patients and healthy controls (all p > 0.05). The association of three main haplotypes (CC, CT, and TC) in FCN1 and three main haplotypes (CT, GA, and GT) in FCN3 with PTB susceptibility was also analyzed, and no significant association was detected (all p > 0.05). In FCN1, the rs1071583 TT genotype was significantly associated with the occurrence of drug resistance in PTB patients (p = 0.040). In addition, the GG genotype and G allele frequencies of rs3813800 in FCN3 gene were significantly higher in PTB patients with pulmonary infection (p = 0.027, p = 0.020, respectively). CONCLUSIONS: FCN1 and FCN3 genetic variation were not contributed to the pathogenesis of PTB in Chinese. While rs1071583 and rs3813800 variant might associate with several clinical characteristics of PTB. John Wiley and Sons Inc. 2021-02-16 /pmc/articles/PMC8059754/ /pubmed/33591573 http://dx.doi.org/10.1002/jcla.23732 Text en © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Li, Ye
You, En‐Qing
Lin, Wen‐Hong
Liu, Xiao‐Ning
Shen, De‐Pei
Zhang, Xin‐Li
Ma, Dong‐Chun
Li, Hong‐Miao
Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population
title Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population
title_full Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population
title_fullStr Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population
title_full_unstemmed Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population
title_short Association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population
title_sort association of ficolin‐1 and ficolin‐3 gene variation and pulmonary tuberculosis susceptibility in a chinese population
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059754/
https://www.ncbi.nlm.nih.gov/pubmed/33591573
http://dx.doi.org/10.1002/jcla.23732
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