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A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth

Salmonella Typhi is a human-restricted bacterial pathogen that causes typhoid fever, a life-threatening systemic infection. A fundamental aspect of S. Typhi pathogenesis is its ability to survive in human macrophages but not in macrophages from other animals (i.e. mice). Despite the importance of ma...

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Detalles Bibliográficos
Autores principales: Solano-Collado, Virtu, Colamarino, Rosa Angela, Calderwood, David A., Baldassarre, Massimiliano, Spanò, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059790/
https://www.ncbi.nlm.nih.gov/pubmed/33898333
http://dx.doi.org/10.3389/fcimb.2021.660689