Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma

Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected by local cellular clustering than global density...

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Detalles Bibliográficos
Autores principales: Chakiryan, Nicholas H., Kimmel, Gregory J., Kim, Youngchul, Hajiran, Ali, Aydin, Ahmet M., Zemp, Logan, Katende, Esther, Nguyen, Jonathan, Lopez-Blanco, Neale, Chahoud, Jad, Spiess, Philippe E., Fournier, Michelle, Dhillon, Jasreman, Wang, Liang, Moran-Segura, Carlos, El-Kenawi, Asmaa, Mulé, James, Altrock, Philipp M., Manley, Brandon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059840/
https://www.ncbi.nlm.nih.gov/pubmed/33882057
http://dx.doi.org/10.1371/journal.pone.0245415

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