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COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059848/ https://www.ncbi.nlm.nih.gov/pubmed/33882097 http://dx.doi.org/10.1371/journal.pone.0250358 |
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author | Kim, Cherry Kim, Wooil Jeon, Ji Hoon Seok, Hyeri Kim, Sun Bean Choi, Hee Kyoung Yoon, Young Kyung Song, Joon Young Park, Dae Won Sohn, Jang Wook Choi, Won Suk |
author_facet | Kim, Cherry Kim, Wooil Jeon, Ji Hoon Seok, Hyeri Kim, Sun Bean Choi, Hee Kyoung Yoon, Young Kyung Song, Joon Young Park, Dae Won Sohn, Jang Wook Choi, Won Suk |
author_sort | Kim, Cherry |
collection | PubMed |
description | Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease severity. In this retrospective study, 106 COVID-19 young patients with asymptomatic or mild disease severity were analyzed for clinical characteristics, clinical course, prevalence of radiologically proven pneumonia and viral load. The cut-off value of viral load for presence of pneumonia was also investigated. The mean age was 28.0±9.3 years. Eleven patients (10.4%) experienced viral remission within one week of diagnosis, but one (0.9%) transferred to the hospital due to aggravation of pneumonia. Patients with pneumonia had significantly higher viral load than those without, and the cut-off value of the Ct value for presence of pneumonia were 31.38. The patients with pneumonia had significantly slower recovery times than those without. Diarrhea was significantly more common in patients with pneumonia than patients without pneumonia. In conclusion, most young asymptomatic and mildly symptomatic patients showed stable clinical course. There were significant differences in viral load and recovery times between patients with and without pneumonia. |
format | Online Article Text |
id | pubmed-8059848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80598482021-05-04 COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load Kim, Cherry Kim, Wooil Jeon, Ji Hoon Seok, Hyeri Kim, Sun Bean Choi, Hee Kyoung Yoon, Young Kyung Song, Joon Young Park, Dae Won Sohn, Jang Wook Choi, Won Suk PLoS One Research Article Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease severity. In this retrospective study, 106 COVID-19 young patients with asymptomatic or mild disease severity were analyzed for clinical characteristics, clinical course, prevalence of radiologically proven pneumonia and viral load. The cut-off value of viral load for presence of pneumonia was also investigated. The mean age was 28.0±9.3 years. Eleven patients (10.4%) experienced viral remission within one week of diagnosis, but one (0.9%) transferred to the hospital due to aggravation of pneumonia. Patients with pneumonia had significantly higher viral load than those without, and the cut-off value of the Ct value for presence of pneumonia were 31.38. The patients with pneumonia had significantly slower recovery times than those without. Diarrhea was significantly more common in patients with pneumonia than patients without pneumonia. In conclusion, most young asymptomatic and mildly symptomatic patients showed stable clinical course. There were significant differences in viral load and recovery times between patients with and without pneumonia. Public Library of Science 2021-04-21 /pmc/articles/PMC8059848/ /pubmed/33882097 http://dx.doi.org/10.1371/journal.pone.0250358 Text en © 2021 Kim et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Kim, Cherry Kim, Wooil Jeon, Ji Hoon Seok, Hyeri Kim, Sun Bean Choi, Hee Kyoung Yoon, Young Kyung Song, Joon Young Park, Dae Won Sohn, Jang Wook Choi, Won Suk COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load |
title | COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load |
title_full | COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load |
title_fullStr | COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load |
title_full_unstemmed | COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load |
title_short | COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load |
title_sort | covid-19 infection with asymptomatic or mild disease severity in young patients: clinical course and association between prevalence of pneumonia and viral load |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059848/ https://www.ncbi.nlm.nih.gov/pubmed/33882097 http://dx.doi.org/10.1371/journal.pone.0250358 |
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