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COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load

Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease s...

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Autores principales: Kim, Cherry, Kim, Wooil, Jeon, Ji Hoon, Seok, Hyeri, Kim, Sun Bean, Choi, Hee Kyoung, Yoon, Young Kyung, Song, Joon Young, Park, Dae Won, Sohn, Jang Wook, Choi, Won Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059848/
https://www.ncbi.nlm.nih.gov/pubmed/33882097
http://dx.doi.org/10.1371/journal.pone.0250358
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author Kim, Cherry
Kim, Wooil
Jeon, Ji Hoon
Seok, Hyeri
Kim, Sun Bean
Choi, Hee Kyoung
Yoon, Young Kyung
Song, Joon Young
Park, Dae Won
Sohn, Jang Wook
Choi, Won Suk
author_facet Kim, Cherry
Kim, Wooil
Jeon, Ji Hoon
Seok, Hyeri
Kim, Sun Bean
Choi, Hee Kyoung
Yoon, Young Kyung
Song, Joon Young
Park, Dae Won
Sohn, Jang Wook
Choi, Won Suk
author_sort Kim, Cherry
collection PubMed
description Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease severity. In this retrospective study, 106 COVID-19 young patients with asymptomatic or mild disease severity were analyzed for clinical characteristics, clinical course, prevalence of radiologically proven pneumonia and viral load. The cut-off value of viral load for presence of pneumonia was also investigated. The mean age was 28.0±9.3 years. Eleven patients (10.4%) experienced viral remission within one week of diagnosis, but one (0.9%) transferred to the hospital due to aggravation of pneumonia. Patients with pneumonia had significantly higher viral load than those without, and the cut-off value of the Ct value for presence of pneumonia were 31.38. The patients with pneumonia had significantly slower recovery times than those without. Diarrhea was significantly more common in patients with pneumonia than patients without pneumonia. In conclusion, most young asymptomatic and mildly symptomatic patients showed stable clinical course. There were significant differences in viral load and recovery times between patients with and without pneumonia.
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spelling pubmed-80598482021-05-04 COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load Kim, Cherry Kim, Wooil Jeon, Ji Hoon Seok, Hyeri Kim, Sun Bean Choi, Hee Kyoung Yoon, Young Kyung Song, Joon Young Park, Dae Won Sohn, Jang Wook Choi, Won Suk PLoS One Research Article Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease severity. In this retrospective study, 106 COVID-19 young patients with asymptomatic or mild disease severity were analyzed for clinical characteristics, clinical course, prevalence of radiologically proven pneumonia and viral load. The cut-off value of viral load for presence of pneumonia was also investigated. The mean age was 28.0±9.3 years. Eleven patients (10.4%) experienced viral remission within one week of diagnosis, but one (0.9%) transferred to the hospital due to aggravation of pneumonia. Patients with pneumonia had significantly higher viral load than those without, and the cut-off value of the Ct value for presence of pneumonia were 31.38. The patients with pneumonia had significantly slower recovery times than those without. Diarrhea was significantly more common in patients with pneumonia than patients without pneumonia. In conclusion, most young asymptomatic and mildly symptomatic patients showed stable clinical course. There were significant differences in viral load and recovery times between patients with and without pneumonia. Public Library of Science 2021-04-21 /pmc/articles/PMC8059848/ /pubmed/33882097 http://dx.doi.org/10.1371/journal.pone.0250358 Text en © 2021 Kim et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kim, Cherry
Kim, Wooil
Jeon, Ji Hoon
Seok, Hyeri
Kim, Sun Bean
Choi, Hee Kyoung
Yoon, Young Kyung
Song, Joon Young
Park, Dae Won
Sohn, Jang Wook
Choi, Won Suk
COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
title COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
title_full COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
title_fullStr COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
title_full_unstemmed COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
title_short COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load
title_sort covid-19 infection with asymptomatic or mild disease severity in young patients: clinical course and association between prevalence of pneumonia and viral load
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059848/
https://www.ncbi.nlm.nih.gov/pubmed/33882097
http://dx.doi.org/10.1371/journal.pone.0250358
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