Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver

Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are key regulators of metabolism. Here, we report a previously unknown function for the hepatic FXR-SHP axis in controlling protein N-linked glycosylation. Transcriptome analysis in liver-specific Fxr-Shp double knockou...

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Detalles Bibliográficos
Autores principales: Mathur, Bhoomika, Shajahan, Asif, Arif, Waqar, Chen, Qiushi, Hand, Nicholas J., Abramowitz, Lara K., Schoonjans, Kristina, Rader, Daniel J., Kalsotra, Auinash, Hanover, John A., Azadi, Parastoo, Anakk, Sayeepriyadarshini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059921/
https://www.ncbi.nlm.nih.gov/pubmed/33883138
http://dx.doi.org/10.1126/sciadv.abf4865

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