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Idiopathic Chronic Eosinophilic Pneumonia
Idiopathic chronic eosinophilic pneumonia (CEP) is a rare disease of unknown cause characterized by eosinophilic alveolar and interstitial infiltration. The authors describe the case of a 46-year-old black man, presenting with insidious onset and progressive course of dyspnea on minimum exertion, co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060025/ https://www.ncbi.nlm.nih.gov/pubmed/33898133 http://dx.doi.org/10.7759/cureus.14047 |
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author | Teixeira, Natália Santos, Maria Inês Pedro, Filipa Pinto, Maria João Mestre, Ana |
author_facet | Teixeira, Natália Santos, Maria Inês Pedro, Filipa Pinto, Maria João Mestre, Ana |
author_sort | Teixeira, Natália |
collection | PubMed |
description | Idiopathic chronic eosinophilic pneumonia (CEP) is a rare disease of unknown cause characterized by eosinophilic alveolar and interstitial infiltration. The authors describe the case of a 46-year-old black man, presenting with insidious onset and progressive course of dyspnea on minimum exertion, cough, fever, night sweats, and weight loss for one year and worsening in the last three months. The main findings were serum eosinophilia. Chest radiographs showed multifocal infiltrations of irregular distribution in both lungs and a restrictive functional impairment. The patient underwent open lung biopsy, and the anatomopathological examination revealed consolidation by exudate constituted predominantly by macrophages (25%) and eosinophils (51%), which filled small air spaces, including respiratory and membranous bronchioles. The anatomopathological diagnosis was eosinophilic pneumonia (eosinophils > 25% is widely accepted for diagnosing eosinophilic pneumonia). The patient had a good clinical response after starting corticosteroid therapy. |
format | Online Article Text |
id | pubmed-8060025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-80600252021-04-23 Idiopathic Chronic Eosinophilic Pneumonia Teixeira, Natália Santos, Maria Inês Pedro, Filipa Pinto, Maria João Mestre, Ana Cureus Internal Medicine Idiopathic chronic eosinophilic pneumonia (CEP) is a rare disease of unknown cause characterized by eosinophilic alveolar and interstitial infiltration. The authors describe the case of a 46-year-old black man, presenting with insidious onset and progressive course of dyspnea on minimum exertion, cough, fever, night sweats, and weight loss for one year and worsening in the last three months. The main findings were serum eosinophilia. Chest radiographs showed multifocal infiltrations of irregular distribution in both lungs and a restrictive functional impairment. The patient underwent open lung biopsy, and the anatomopathological examination revealed consolidation by exudate constituted predominantly by macrophages (25%) and eosinophils (51%), which filled small air spaces, including respiratory and membranous bronchioles. The anatomopathological diagnosis was eosinophilic pneumonia (eosinophils > 25% is widely accepted for diagnosing eosinophilic pneumonia). The patient had a good clinical response after starting corticosteroid therapy. Cureus 2021-03-22 /pmc/articles/PMC8060025/ /pubmed/33898133 http://dx.doi.org/10.7759/cureus.14047 Text en Copyright © 2021, Teixeira et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Teixeira, Natália Santos, Maria Inês Pedro, Filipa Pinto, Maria João Mestre, Ana Idiopathic Chronic Eosinophilic Pneumonia |
title | Idiopathic Chronic Eosinophilic Pneumonia |
title_full | Idiopathic Chronic Eosinophilic Pneumonia |
title_fullStr | Idiopathic Chronic Eosinophilic Pneumonia |
title_full_unstemmed | Idiopathic Chronic Eosinophilic Pneumonia |
title_short | Idiopathic Chronic Eosinophilic Pneumonia |
title_sort | idiopathic chronic eosinophilic pneumonia |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060025/ https://www.ncbi.nlm.nih.gov/pubmed/33898133 http://dx.doi.org/10.7759/cureus.14047 |
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