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Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease

INTRODUCTION: Postural instability is commonly observed in Parkinson's disease, leading to an increasing risk of falling and worsening as the disease progresses. We found that limit of stability can be applied to reflect the dynamic evolution of postural instability in patients with Parkinson&#...

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Autores principales: Yu, Yang, Liang, Siquan, Wang, Yue, Zhao, Yanan, Zhao, Jiaojiao, Li, Haitao, Wu, Jingchao, Cheng, Yuanyuan, Wu, Fan, Wu, Jialing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060093/
https://www.ncbi.nlm.nih.gov/pubmed/33936583
http://dx.doi.org/10.1155/2021/5681870
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author Yu, Yang
Liang, Siquan
Wang, Yue
Zhao, Yanan
Zhao, Jiaojiao
Li, Haitao
Wu, Jingchao
Cheng, Yuanyuan
Wu, Fan
Wu, Jialing
author_facet Yu, Yang
Liang, Siquan
Wang, Yue
Zhao, Yanan
Zhao, Jiaojiao
Li, Haitao
Wu, Jingchao
Cheng, Yuanyuan
Wu, Fan
Wu, Jialing
author_sort Yu, Yang
collection PubMed
description INTRODUCTION: Postural instability is commonly observed in Parkinson's disease, leading to an increasing risk of falling and worsening as the disease progresses. We found that limit of stability can be applied to reflect the dynamic evolution of postural instability in patients with Parkinson's disease. METHODS: Forty-three patients (9 of Hoehn and Yahr stage I, 12 of stage II, 14 of stage III, and 8 of stage IV) met the criteria for the diagnosis of idiopathic Parkinson's disease and could stand independently for at least 10 minutes. Twelve healthy controls with no sign of parkinsonism were also recruited. Postural instability was assessed by posturography in different directions (forward, backward, right, left, forward-right, forward-left, backward-right, and backward-left). This study trial was registered with the Chinese Clinical Trial Registry (no. ChiCTR1900022715). RESULTS: All participants were able to complete the limit of stability tasks without any complications. Patients in stages II to IV exhibited smaller end point excursion and slower time to complete than controls, suggesting an impaired limit of stability. The patients in stage II exhibited a remarkable decline in most directions compared to controls, except for right and left, and forward and backward decline occurred the earliest. For patients in stage III, right was the only direction with no significant difference from controls. In stage IV patients, the limit of stability declined significantly in all directions (p < 0.05). CONCLUSIONS: The postural abnormalities of Parkinson's disease can occur at early stages, and the pattern of decline is more severe in the forward-backward direction. This trial is registered with ChiCTR1900022715.
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spelling pubmed-80600932021-04-29 Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease Yu, Yang Liang, Siquan Wang, Yue Zhao, Yanan Zhao, Jiaojiao Li, Haitao Wu, Jingchao Cheng, Yuanyuan Wu, Fan Wu, Jialing Parkinsons Dis Research Article INTRODUCTION: Postural instability is commonly observed in Parkinson's disease, leading to an increasing risk of falling and worsening as the disease progresses. We found that limit of stability can be applied to reflect the dynamic evolution of postural instability in patients with Parkinson's disease. METHODS: Forty-three patients (9 of Hoehn and Yahr stage I, 12 of stage II, 14 of stage III, and 8 of stage IV) met the criteria for the diagnosis of idiopathic Parkinson's disease and could stand independently for at least 10 minutes. Twelve healthy controls with no sign of parkinsonism were also recruited. Postural instability was assessed by posturography in different directions (forward, backward, right, left, forward-right, forward-left, backward-right, and backward-left). This study trial was registered with the Chinese Clinical Trial Registry (no. ChiCTR1900022715). RESULTS: All participants were able to complete the limit of stability tasks without any complications. Patients in stages II to IV exhibited smaller end point excursion and slower time to complete than controls, suggesting an impaired limit of stability. The patients in stage II exhibited a remarkable decline in most directions compared to controls, except for right and left, and forward and backward decline occurred the earliest. For patients in stage III, right was the only direction with no significant difference from controls. In stage IV patients, the limit of stability declined significantly in all directions (p < 0.05). CONCLUSIONS: The postural abnormalities of Parkinson's disease can occur at early stages, and the pattern of decline is more severe in the forward-backward direction. This trial is registered with ChiCTR1900022715. Hindawi 2021-04-13 /pmc/articles/PMC8060093/ /pubmed/33936583 http://dx.doi.org/10.1155/2021/5681870 Text en Copyright © 2021 Yang Yu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yu, Yang
Liang, Siquan
Wang, Yue
Zhao, Yanan
Zhao, Jiaojiao
Li, Haitao
Wu, Jingchao
Cheng, Yuanyuan
Wu, Fan
Wu, Jialing
Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease
title Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease
title_full Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease
title_fullStr Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease
title_full_unstemmed Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease
title_short Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease
title_sort quantitative analysis of postural instability in patients with parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060093/
https://www.ncbi.nlm.nih.gov/pubmed/33936583
http://dx.doi.org/10.1155/2021/5681870
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