Teasing apart the cell death pathways in HIV pathogenesis

The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome...

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Autor principal: Montague-Cardoso, Karli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060248/
https://www.ncbi.nlm.nih.gov/pubmed/33883686
http://dx.doi.org/10.1038/s42003-021-02077-2
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author Montague-Cardoso, Karli
author_facet Montague-Cardoso, Karli
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description The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome pathway, which plays a key role in innate immunity, is a crucial mediator of the loss of CD4 + T cells. This advance could inform the development of innovative anti-HIV-1 therapies.
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spelling pubmed-80602482021-05-05 Teasing apart the cell death pathways in HIV pathogenesis Montague-Cardoso, Karli Commun Biol Research Highlight The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome pathway, which plays a key role in innate immunity, is a crucial mediator of the loss of CD4 + T cells. This advance could inform the development of innovative anti-HIV-1 therapies. Nature Publishing Group UK 2021-04-21 /pmc/articles/PMC8060248/ /pubmed/33883686 http://dx.doi.org/10.1038/s42003-021-02077-2 Text en © Springer Nature Limited 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Highlight
Montague-Cardoso, Karli
Teasing apart the cell death pathways in HIV pathogenesis
title Teasing apart the cell death pathways in HIV pathogenesis
title_full Teasing apart the cell death pathways in HIV pathogenesis
title_fullStr Teasing apart the cell death pathways in HIV pathogenesis
title_full_unstemmed Teasing apart the cell death pathways in HIV pathogenesis
title_short Teasing apart the cell death pathways in HIV pathogenesis
title_sort teasing apart the cell death pathways in hiv pathogenesis
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060248/
https://www.ncbi.nlm.nih.gov/pubmed/33883686
http://dx.doi.org/10.1038/s42003-021-02077-2
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