Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of VWF becomes activated and captures platelets via the GPIb-IX complex. Here we show that the shear-responsive elem...

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Detalles Bibliográficos
Autores principales: Arce, Nicholas A., Cao, Wenpeng, Brown, Alexander K., Legan, Emily R., Wilson, Moriah S., Xu, Emma-Ruoqi, Berndt, Michael C., Emsley, Jonas, Zhang, X. Frank, Li, Renhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060278/
https://www.ncbi.nlm.nih.gov/pubmed/33883551
http://dx.doi.org/10.1038/s41467-021-22634-x

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