Cargando…

EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines

In epithelial cancers, the epidermal growth factor receptor (EGFR) and integrin α6β4 are frequently overexpressed and found to synergistically activate intracellular signaling pathways that promote cell proliferation and migration. In cancer cells, the β4 subunit is phosphorylated at tyrosine residu...

Descripción completa

Detalles Bibliográficos
Autores principales:	te Molder, Lisa, Kreft, Maaike, Heemskerk, Niels, Schuring, Joyce, de Pereda, Jose M., Wilhelmsen, Kevin, Sonnenberg, Arnoud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060419/ https://www.ncbi.nlm.nih.gov/pubmed/33883672 http://dx.doi.org/10.1038/s41598-021-88134-6

Ejemplares similares

PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736
por: te Molder, Lisa, et al.
Publicado: (2015)

Comparative interactomics analysis reveals potential regulators of α6β4 distribution in keratinocytes
por: te Molder, Lisa, et al.
Publicado: (2020)

Kindlin-1 Regulates Integrin Dynamics and Adhesion Turnover
por: Margadant, Coert, et al.
Publicado: (2013)

PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins
por: Zuidema, Alba, et al.
Publicado: (2022)

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly
por: Frijns, Evelyne, et al.
Publicado: (2012)

Absence of integrin α3β1 promotes the progression of HER2-driven breast cancer in vivo
por: Ramovs, Veronika, et al.
Publicado: (2019)

Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis
por: Ketema, Mirjam, et al.
Publicado: (2013)

Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis
por: Ramovs, Veronika, et al.
Publicado: (2020)

Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin β subunits
por: van der Flier, Arjan, et al.
Publicado: (2002)

The rod domain is not essential for the function of plectin in maintaining tissue integrity
por: Ketema, Mirjam, et al.
Publicado: (2015)

Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro
por: Verma, Rakesh, et al.
Publicado: (2016)

The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes
Publicado: (1994)

Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins
por: Romagnoli, Mathilde, et al.
Publicado: (2019)

Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins
por: Romagnoli, Mathilde, et al.
Publicado: (2019)

Hemidesmosomes modulate force generation via focal adhesions
por: Wang, Wei, et al.
Publicado: (2020)

The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour
por: Høye, Anette M., et al.
Publicado: (2016)

Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils
Publicado: (1994)

EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
por: Ando, Toshinori, et al.
Publicado: (2021)

Imaging and quantitative analysis of integrin-dependent cell-matrix adhesions
por: van Stalborch, Anne-Marieke D., et al.
Publicado: (2023)

Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin α6β4
por: Alonso-García, Noelia, et al.
Publicado: (2015)

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets
Publicado: (1992)

Altered localization and cytoplasmic domain-binding properties of tyrosine-phosphorylated beta 1 integrin
Publicado: (1994)

Integrin β(3) Crosstalk with VEGFR Accommodating Tyrosine Phosphorylation as a Regulatory Switch
por: West, Xiaoxia Z., et al.
Publicado: (2012)

Alteration in tyrosine phosphorylation of cardiac proteome and EGFR pathway contribute to hypertrophic cardiomyopathy
por: Xu, Mingguo, et al.
Publicado: (2022)

Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation
por: Hayashi, Takashi
Publicado: (2022)

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors
Publicado: (1996)

Molecular determinants of αVβ5 localization in flat clathrin lattices – role of αVβ5 in cell adhesion and proliferation
por: Zuidema, Alba, et al.
Publicado: (2022)

Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors
Publicado: (1996)

Beta 2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor
Publicado: (1994)

Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin–talin switch
por: Ling, Kun, et al.
Publicado: (2003)

Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo
por: Bezman, Natalie A., et al.
Publicado: (2008)

Tyrosine phosphorylation is required for Fc receptor-mediated phagocytosis in mouse macrophages
Publicado: (1993)

Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis
por: Confalonieri, Stefano, et al.
Publicado: (2000)

Integrins control motile strategy through a Rho–cofilin pathway
por: Danen, Erik H.J., et al.
Publicado: (2005)

The role of RICTOR downstream of receptor tyrosine kinase in cancers
por: Jebali, Ahlem, et al.
Publicado: (2018)

Induction of Cell Scattering by Expression of β1 Integrins in β1-Deficient Epithelial Cells Requires Activation of Members of the Rho Family of Gtpases and Downregulation of Cadherin and Catenin Function
por: Gimond, Clotilde, et al.
Publicado: (1999)

An MBoC Favorite: Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein
por: Adams, Josephine C.
Publicado: (2012)

Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783
por: Tian, Wei, et al.
Publicado: (2012)

Kidney failure in mice lacking the tetraspanin CD151
por: Sachs, Norman, et al.
Publicado: (2006)

Agrin-induced acetylcholine receptor clustering in mammalian muscle requires tyrosine phosphorylation
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_5esu3lnpep7n5gkrra0s2fitvs