Cargando…

Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent

Neurologic manifestations associated with Covid-19 are increasingly reported, especially stroke and acute cerebrovascular events. Beyond cardiovascular risk factors associated with age, some young adults without medical or cardiovascular history had stroke as a presenting feature of Covid-19. Sugges...

Descripción completa

Detalles Bibliográficos
Autores principales: de Marcellus, Charles, Dupic, Laurent, Roux, Charles-Joris, El Aouane El Ghomari, Imane, Parize, Perrine, Luscan, Romain, Moulin, Florence, Kossorotoff, Manoelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060448/
https://www.ncbi.nlm.nih.gov/pubmed/33897582
http://dx.doi.org/10.3389/fneur.2021.606617
_version_ 1783681364785102848
author de Marcellus, Charles
Dupic, Laurent
Roux, Charles-Joris
El Aouane El Ghomari, Imane
Parize, Perrine
Luscan, Romain
Moulin, Florence
Kossorotoff, Manoelle
author_facet de Marcellus, Charles
Dupic, Laurent
Roux, Charles-Joris
El Aouane El Ghomari, Imane
Parize, Perrine
Luscan, Romain
Moulin, Florence
Kossorotoff, Manoelle
author_sort de Marcellus, Charles
collection PubMed
description Neurologic manifestations associated with Covid-19 are increasingly reported, especially stroke and acute cerebrovascular events. Beyond cardiovascular risk factors associated with age, some young adults without medical or cardiovascular history had stroke as a presenting feature of Covid-19. Suggested stroke mechanisms in this setting are inflammatory storm, subsequent hypercoagulability, and vasculitis. To date, a handful of pediatric stroke cases associated with Covid-19 have been reported, either with a cardioembolic mechanism or a focal cerebral arteriopathy. We report the case of an adolescent who presented with febrile meningism and stupor. Clinical, biological, and radiological features favored the diagnosis of Lemierre syndrome (LS), with Fusobacterium necrophorum infection (sphenoid sinusitis and meningitis) and intracranial vasculitis. The patient had concurrent SARS-CoV-2 infection. Despite medical and surgical antimicrobial treatment, stroke prevention, and venous thrombosis prevention, he presented with severe cerebrovascular complications. Venous thrombosis and stroke were observed, with an extension of intracranial vasculitis, and lead to death. As both F. necrophorum and SARS-CoV-2 enhance inflammation, coagulation, and activate endothelial cells, we discuss how this coinfection may have potentiated and aggravated the usual course of LS. The potentiation by SARS-CoV-2 of vascular and thrombotic effects of a bacterial infection may represent an underreported cerebrovascular injury mechanism in Covid-19 patients. These findings emphasize the variety of mechanisms underlying stroke in this disease. Moreover, in the setting of SARS-CoV-2 pandemic, we discuss in what extent sanitary measures, namely, lockdown and fear to attend medical facilities, may have delayed diagnosis and influenced outcomes. This case also emphasizes the role of clinical assessment and the limits of telemedicine for acute neurological condition diagnosis.
format Online
Article
Text
id pubmed-8060448
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80604482021-04-23 Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent de Marcellus, Charles Dupic, Laurent Roux, Charles-Joris El Aouane El Ghomari, Imane Parize, Perrine Luscan, Romain Moulin, Florence Kossorotoff, Manoelle Front Neurol Neurology Neurologic manifestations associated with Covid-19 are increasingly reported, especially stroke and acute cerebrovascular events. Beyond cardiovascular risk factors associated with age, some young adults without medical or cardiovascular history had stroke as a presenting feature of Covid-19. Suggested stroke mechanisms in this setting are inflammatory storm, subsequent hypercoagulability, and vasculitis. To date, a handful of pediatric stroke cases associated with Covid-19 have been reported, either with a cardioembolic mechanism or a focal cerebral arteriopathy. We report the case of an adolescent who presented with febrile meningism and stupor. Clinical, biological, and radiological features favored the diagnosis of Lemierre syndrome (LS), with Fusobacterium necrophorum infection (sphenoid sinusitis and meningitis) and intracranial vasculitis. The patient had concurrent SARS-CoV-2 infection. Despite medical and surgical antimicrobial treatment, stroke prevention, and venous thrombosis prevention, he presented with severe cerebrovascular complications. Venous thrombosis and stroke were observed, with an extension of intracranial vasculitis, and lead to death. As both F. necrophorum and SARS-CoV-2 enhance inflammation, coagulation, and activate endothelial cells, we discuss how this coinfection may have potentiated and aggravated the usual course of LS. The potentiation by SARS-CoV-2 of vascular and thrombotic effects of a bacterial infection may represent an underreported cerebrovascular injury mechanism in Covid-19 patients. These findings emphasize the variety of mechanisms underlying stroke in this disease. Moreover, in the setting of SARS-CoV-2 pandemic, we discuss in what extent sanitary measures, namely, lockdown and fear to attend medical facilities, may have delayed diagnosis and influenced outcomes. This case also emphasizes the role of clinical assessment and the limits of telemedicine for acute neurological condition diagnosis. Frontiers Media S.A. 2021-04-08 /pmc/articles/PMC8060448/ /pubmed/33897582 http://dx.doi.org/10.3389/fneur.2021.606617 Text en Copyright © 2021 de Marcellus, Dupic, Roux, El Aouane El Ghomari, Parize, Luscan, Moulin and Kossorotoff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
de Marcellus, Charles
Dupic, Laurent
Roux, Charles-Joris
El Aouane El Ghomari, Imane
Parize, Perrine
Luscan, Romain
Moulin, Florence
Kossorotoff, Manoelle
Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent
title Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent
title_full Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent
title_fullStr Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent
title_full_unstemmed Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent
title_short Case Report: Cerebrovascular Events Associated With Bacterial and SARS-CoV-2 Infections in an Adolescent
title_sort case report: cerebrovascular events associated with bacterial and sars-cov-2 infections in an adolescent
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060448/
https://www.ncbi.nlm.nih.gov/pubmed/33897582
http://dx.doi.org/10.3389/fneur.2021.606617
work_keys_str_mv AT demarcelluscharles casereportcerebrovasculareventsassociatedwithbacterialandsarscov2infectionsinanadolescent
AT dupiclaurent casereportcerebrovasculareventsassociatedwithbacterialandsarscov2infectionsinanadolescent
AT rouxcharlesjoris casereportcerebrovasculareventsassociatedwithbacterialandsarscov2infectionsinanadolescent
AT elaouaneelghomariimane casereportcerebrovasculareventsassociatedwithbacterialandsarscov2infectionsinanadolescent
AT parizeperrine casereportcerebrovasculareventsassociatedwithbacterialandsarscov2infectionsinanadolescent
AT luscanromain casereportcerebrovasculareventsassociatedwithbacterialandsarscov2infectionsinanadolescent
AT moulinflorence casereportcerebrovasculareventsassociatedwithbacterialandsarscov2infectionsinanadolescent
AT kossorotoffmanoelle casereportcerebrovasculareventsassociatedwithbacterialandsarscov2infectionsinanadolescent