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Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate

Significance: The importance of oxidoreductases in energy metabolism together with the occurrence of enzymes of central metabolism in the nucleus gave rise to the active research field aiming to understand moonlighting enzymes that undergo post-translational modifications (PTMs) before carrying out...

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Autores principales: Selinski, Jennifer, Scheibe, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060724/
https://www.ncbi.nlm.nih.gov/pubmed/32620064
http://dx.doi.org/10.1089/ars.2020.8121
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author Selinski, Jennifer
Scheibe, Renate
author_facet Selinski, Jennifer
Scheibe, Renate
author_sort Selinski, Jennifer
collection PubMed
description Significance: The importance of oxidoreductases in energy metabolism together with the occurrence of enzymes of central metabolism in the nucleus gave rise to the active research field aiming to understand moonlighting enzymes that undergo post-translational modifications (PTMs) before carrying out new tasks. Recent Advances: Cytosolic enzymes were shown to induce gene transcription after PTM and concomitant translocation to the nucleus. Changed properties of the oxidized forms of cytosolic glyceraldehyde 3-phosphate dehydrogenase, and also malate dehydrogenases and others, are the basis for a hypothesis suggesting moonlighting functions that directly link energy metabolism to adaptive responses required for maintenance of redox-homeostasis in all eukaryotes. Critical Issues: Small molecules, such as metabolic intermediates, coenzymes, or reduced glutathione, were shown to fine-tune the redox switches, interlinking redox state, metabolism, and induction of new functions via nuclear gene expression. The cytosol with its metabolic enzymes connecting energy fluxes between the various cell compartments can be seen as a hub for redox signaling, integrating the different signals for graded and directed responses in stressful situations. Future Directions: Enzymes of central metabolism were shown to interact with p53 or the assumed plant homologue suppressor of gamma response 1 (SOG1), an NAM, ATAF, and CUC transcription factor involved in the stress response upon ultraviolet exposure. Metabolic enzymes serve as sensors for imbalances, their inhibition leading to changed energy metabolism, and the adoption of transcriptional coactivator activities. Depending on the intensity of the impact, rerouting of energy metabolism, proliferation, DNA repair, cell cycle arrest, immune responses, or cell death will be induced. Antioxid. Redox Signal. 34, 1025–1047.
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spelling pubmed-80607242021-04-22 Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate Selinski, Jennifer Scheibe, Renate Antioxid Redox Signal Metabolic Redox-Switches and Moonlighting Proteins (Ed. Myra Conway) Significance: The importance of oxidoreductases in energy metabolism together with the occurrence of enzymes of central metabolism in the nucleus gave rise to the active research field aiming to understand moonlighting enzymes that undergo post-translational modifications (PTMs) before carrying out new tasks. Recent Advances: Cytosolic enzymes were shown to induce gene transcription after PTM and concomitant translocation to the nucleus. Changed properties of the oxidized forms of cytosolic glyceraldehyde 3-phosphate dehydrogenase, and also malate dehydrogenases and others, are the basis for a hypothesis suggesting moonlighting functions that directly link energy metabolism to adaptive responses required for maintenance of redox-homeostasis in all eukaryotes. Critical Issues: Small molecules, such as metabolic intermediates, coenzymes, or reduced glutathione, were shown to fine-tune the redox switches, interlinking redox state, metabolism, and induction of new functions via nuclear gene expression. The cytosol with its metabolic enzymes connecting energy fluxes between the various cell compartments can be seen as a hub for redox signaling, integrating the different signals for graded and directed responses in stressful situations. Future Directions: Enzymes of central metabolism were shown to interact with p53 or the assumed plant homologue suppressor of gamma response 1 (SOG1), an NAM, ATAF, and CUC transcription factor involved in the stress response upon ultraviolet exposure. Metabolic enzymes serve as sensors for imbalances, their inhibition leading to changed energy metabolism, and the adoption of transcriptional coactivator activities. Depending on the intensity of the impact, rerouting of energy metabolism, proliferation, DNA repair, cell cycle arrest, immune responses, or cell death will be induced. Antioxid. Redox Signal. 34, 1025–1047. Mary Ann Liebert, Inc., publishers 2021-05-01 2021-04-07 /pmc/articles/PMC8060724/ /pubmed/32620064 http://dx.doi.org/10.1089/ars.2020.8121 Text en © Jennifer Selinski and Renate Scheibe 2021; Published by Mary Ann Liebert, Inc. https://creativecommons.org/licenses/by-nc/4.0/This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License [CC-BY-NC] (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.
spellingShingle Metabolic Redox-Switches and Moonlighting Proteins (Ed. Myra Conway)
Selinski, Jennifer
Scheibe, Renate
Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate
title Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate
title_full Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate
title_fullStr Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate
title_full_unstemmed Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate
title_short Central Metabolism in Mammals and Plants as a Hub for Controlling Cell Fate
title_sort central metabolism in mammals and plants as a hub for controlling cell fate
topic Metabolic Redox-Switches and Moonlighting Proteins (Ed. Myra Conway)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060724/
https://www.ncbi.nlm.nih.gov/pubmed/32620064
http://dx.doi.org/10.1089/ars.2020.8121
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