Cargando…

Implications of extreme serum neurofilament light chain levels for the management of patients with relapsing multiple sclerosis

BACKGROUND: Serum neurofilament light chain (sNfL) is a promising biomarker to complement the decision-making process in multiple sclerosis (MS) patients. However, although sNfL levels are able to detect disease activity and to predict future disability, the growing evidence has not yet been transla...

Descripción completa

Detalles Bibliográficos
Autores principales:	Engel, Sinah, Protopapa, Maria, Steffen, Falk, Papanastasiou, Vakis, Nicolaou, Christoforos, Protopapas, Michalis, Zipp, Frauke, Bittner, Stefan, Luessi, Felix
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060778/ https://www.ncbi.nlm.nih.gov/pubmed/33959194 http://dx.doi.org/10.1177/17562864211001977

Ejemplares similares

Elevated neurofilament light chain CSF/serum ratio indicates impaired CSF outflow in idiopathic intracranial hypertension
por: Engel, Sinah, et al.
Publicado: (2023)

Association of serum neurofilament light chain levels and neuropsychiatric manifestations in systemic lupus erythematosus
por: Engel, Sinah, et al.
Publicado: (2021)

Impact of Dietary Intervention on Serum Neurofilament Light Chain in Multiple Sclerosis
por: Bock, Markus, et al.
Publicado: (2021)

Supplementary medication in multiple sclerosis: Real-world experience and potential interference with neurofilament light chain measurement
por: Pape, Katrin, et al.
Publicado: (2020)

Serum Neurofilament Identifies Patients With Multiple Sclerosis With Severe Focal Axonal Damage in a 6-Year Longitudinal Cohort
por: Steffen, Falk, et al.
Publicado: (2022)

Association of intrathecal pleocytosis and IgG synthesis with axonal damage in early MS
por: Engel, Sinah, et al.
Publicado: (2020)

GFAPα IgG-associated encephalitis upon daclizumab treatment of MS
por: Luessi, Felix, et al.
Publicado: (2018)

A Case of Progressive Multifocal Leukoencephalopathy in a Fumaric Acid-Treated Psoriasis Patient With Severe Lymphopenia Among Other Risk Factors
por: Engel, Sinah, et al.
Publicado: (2021)

Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS
por: Engel, Sinah, et al.
Publicado: (2019)

PPMS onset upon adalimumab treatment extends the spectrum of anti-TNF-α therapy-associated demyelinating disorders
por: Engel, Sinah, et al.
Publicado: (2020)

Preventing disease progression in multiple sclerosis—insights from large real-world cohorts
por: Engel, Sinah, et al.
Publicado: (2022)

The potential of serum neurofilament as biomarker for multiple sclerosis
por: Bittner, Stefan, et al.
Publicado: (2021)

Spatial transcriptomics and neurofilament light chain reveal changes in lesion patterns in murine autoimmune neuroinflammation
por: Brummer, Tobias, et al.
Publicado: (2023)

NfL predicts relapse-free progression in a longitudinal multiple sclerosis cohort study: Serum NfL predicts relapse-free progression
por: Uphaus, Timo, et al.
Publicado: (2021)

Serum neurofilament levels reflect outer retinal layer changes in multiple sclerosis
por: Seitz, Caspar B., et al.
Publicado: (2021)

Attenuation of immune activation in patients with multiple sclerosis on a wheat-reduced diet: a pilot crossover trial
por: Engel, Sinah, et al.
Publicado: (2023)

Ocrelizumab-induced vulvovaginal pyoderma gangrenosum in a patient with relapsing-remitting multiple sclerosis
por: Klumpp, Annika, et al.
Publicado: (2022)

Association Between Serum Levels of Neurofilament Light Chains and Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis
por: Labenz, Christian, et al.
Publicado: (2021)

Exercise Diminishes Plasma Neurofilament Light Chain and Reroutes the Kynurenine Pathway in Multiple Sclerosis
por: Joisten, Niklas, et al.
Publicado: (2021)

Fingolimod and CSF neurofilament light chain levels in relapsing-remitting multiple sclerosis
por: Kuhle, Jens, et al.
Publicado: (2015)

Network alterations underlying anxiety symptoms in early multiple sclerosis
por: Ellwardt, Erik, et al.
Publicado: (2022)

Natural Variation of Vitamin D and Neurofilament Light Chain in Relapsing-Remitting Multiple Sclerosis
por: Røsjø, Egil, et al.
Publicado: (2020)

The Evolution of Neurofilament Light Chain in Multiple Sclerosis
por: Ferreira-Atuesta, Carolina, et al.
Publicado: (2021)

Kynurenines and Neurofilament Light Chain in Multiple Sclerosis
por: Pukoli, Dániel, et al.
Publicado: (2021)

Comparative effectiveness of natalizumab versus ocrelizumab in multiple sclerosis: a real-world propensity score–matched study
por: Pape, Katrin, et al.
Publicado: (2022)

MOG encephalomyelitis: distinct clinical, MRI and CSF features in patients with longitudinal extensive transverse myelitis as first clinical presentation
por: Loos, Julia, et al.
Publicado: (2020)

Improved prediction of early cognitive impairment in multiple sclerosis combining blood and imaging biomarkers
por: Brummer, Tobias, et al.
Publicado: (2022)

Neurofilament Light Chain as a Biomarker in Multiple Sclerosis
por: Varhaug, Kristin N., et al.
Publicado: (2019)

Cardiotoxicity of Mitoxantrone Treatment in a German Cohort of 639 Multiple Sclerosis Patients
por: Fleischer, Vinzenz, et al.
Publicado: (2014)

Neurofilament light chain predicts disease activity in relapsing-remitting MS
por: Varhaug, Kristin N., et al.
Publicado: (2017)

Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study
por: Bittner, Stefan, et al.
Publicado: (2020)

Continuous reorganization of cortical information flow in multiple sclerosis: A longitudinal fMRI effective connectivity study
por: Fleischer, Vinzenz, et al.
Publicado: (2020)

Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders
por: Brummer, Tobias, et al.
Publicado: (2021)

Neurofilament light chain as a biomarker for diagnosis of multiple sclerosis
por: Kouchaki, Ebrahim, et al.
Publicado: (2021)

The prognostic significance of early blood neurofilament light chain concentration and magnetic resonance imaging variables in relapse‐onset multiple sclerosis
por: Williams, Thomas, et al.
Publicado: (2022)

Absolute serum neurofilament light chain levels and its early kinetics predict brain injury after out-of-hospital cardiac arrest
por: Adler, Christoph, et al.
Publicado: (2021)

Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis
por: Lu, Ching-Hua, et al.
Publicado: (2015)

Neurofilament Light Chain as Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
por: Verde, Federico, et al.
Publicado: (2021)

Decreased neurofilament light chain levels in estriol‐treated multiple sclerosis
por: Voskuhl, Rhonda, et al.
Publicado: (2022)

Predictors for insufficient SARS-CoV-2 vaccination response upon treatment in multiple sclerosis
por: Schraad, Muriel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ctpg35fm57s60jgt9vte46ln3q