Cargando…

Critical Assessment of Important Regions in the Subunit Association and Catalytic Action of the Severe Acute Respiratory Syndrome Coronavirus Main Protease

The severe acute respiratory syndrome (SARS) coronavirus (CoV) main protease represents an attractive target for the development of novel anti-SARS agents. The tertiary structure of the protease consists of two distinct folds. One is the N-terminal chymotrypsin-like fold that consists of two structu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hsu, Wen-Chi, Chang, Hui-Chuan, Chou, Chi-Yuan, Tsai, Pui-Jen, Lin, Pei-In, Chang, Gu-Gang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2005
Materias:	Enzyme Catalysis and Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060872/ https://www.ncbi.nlm.nih.gov/pubmed/15831489 http://dx.doi.org/10.1074/jbc.M502556200

Ejemplares similares

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
por: Lee, Cheng-Chung, et al.
Publicado: (2009)

A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition
por: O'Brien, Theresa C., et al.
Publicado: (2008)

Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations
por: Futai, Eugene, et al.
Publicado: (2009)

Porphyrins Promote the Association of GENOMES UNCOUPLED 4 and a Mg-chelatase Subunit with Chloroplast Membranes
por: Adhikari, Neil D., et al.
Publicado: (2009)

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase
por: Beran, Rudolf K. F., et al.
Publicado: (2008)

SARS Coronavirus, but Not Human Coronavirus NL63, Utilizes Cathepsin L to Infect ACE2-expressing Cells
por: Huang, I-Chueh, et al.
Publicado: (2006)

Plasminogen Activator Inhibitor-1 Is an Inhibitor of Factor VII-activating Protease in Patients with Acute Respiratory Distress Syndrome
por: Wygrecka, Malgorzata, et al.
Publicado: (2007)

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase
por: Fan, Keqiang, et al.
Publicado: (2004)

The Severe Acute Respiratory Syndrome (SARS) Coronavirus NTPase/Helicase Belongs to a Distinct Class of 5′ to 3′ Viral Helicases
por: Tanner, Julian A., et al.
Publicado: (2003)

The Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus Inhibits the Activity of Cyclin-Cyclin-dependent Kinase Complex and Blocks S Phase Progression in Mammalian Cells
por: Surjit, Milan, et al.
Publicado: (2006)

SufA of the Opportunistic Pathogen Finegoldia magna Modulates Actions of the Antibacterial Chemokine MIG/CXCL9, Promoting Bacterial Survival during Epithelial Inflammation
por: Karlsson, Christofer, et al.
Publicado: (2009)

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase
por: Briggs, Louise C., et al.
Publicado: (2008)

Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases
por: Beretta, Matteo, et al.
Publicado: (2008)

Leishmania Trypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities
por: Fyfe, Paul K., et al.
Publicado: (2008)

Connection Domain Mutations N348I and A360V in HIV-1 Reverse Transcriptase Enhance Resistance to 3′-Azido-3′-deoxythymidine through Both RNase H-dependent and -independent Mechanisms
por: Ehteshami, Maryam, et al.
Publicado: (2008)

Partially Irreversible Inactivation of Mitochondrial Aldehyde Dehydrogenase by Nitroglycerin
por: Beretta, Matteo, et al.
Publicado: (2008)

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H(2) into Prostaglandin F(2α)
por: Hammarberg, Tove, et al.
Publicado: (2009)

Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)
por: Finn, Robert D., et al.
Publicado: (2008)

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase
por: Baron, Rudi A., et al.
Publicado: (2009)

Selective Inhibition of Carotenoid Cleavage Dioxygenases: PHENOTYPIC EFFECTS ON SHOOT BRANCHING
por: Sergeant, Martin J., et al.
Publicado: (2009)

Regulation of Chemerin Bioactivity by Plasma Carboxypeptidase N, Carboxypeptidase B (Activated Thrombin-activable Fibrinolysis Inhibitor), and Platelets
por: Du, Xiao-Yan, et al.
Publicado: (2009)

Instability of Superoxide Dismutase 1 of Drosophila in Mutants Deficient for Its Cognate Copper Chaperone
por: Kirby, Kim, et al.
Publicado: (2008)

Biochemical, Functional, and Pharmacological Characterization of AT-56, an Orally Active and Selective Inhibitor of Lipocalin-type Prostaglandin D Synthase
por: Irikura, Daisuke, et al.
Publicado: (2009)

Characterization and Inhibition of a Class II Diterpene Cyclase from Mycobacterium tuberculosis: IMPLICATIONS FOR TUBERCULOSIS
por: Mann, Francis M., et al.
Publicado: (2009)

Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin
por: Albet-Torres, Nuria, et al.
Publicado: (2009)

The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity: INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS
por: Miller, Thomas W., et al.
Publicado: (2009)

Heme Regulatory Motifs in Heme Oxygenase-2 Form a Thiol/Disulfide Redox Switch That Responds to the Cellular Redox State
por: Yi, Li, et al.
Publicado: (2009)

Role of the General Base Glu-268 in Nitroglycerin Bioactivation and Superoxide Formation by Aldehyde Dehydrogenase-2
por: Wenzl, M. Verena, et al.
Publicado: (2009)

Global Consequences of Activation Loop Phosphorylation on Protein Kinase A
por: Steichen, Jon M., et al.
Publicado: (2010)

Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2: BIOACTIVATION OF NITROGLYCERIN AND EFFECTS OF Alda-1
por: Beretta, Matteo, et al.
Publicado: (2010)

The Significance of EXDD and RXKD Motif Conservation in Rel Proteins
por: Sajish, Mathew, et al.
Publicado: (2009)

Properties of the Thioredoxin Fold Superfamily Are Modulated by a Single Amino Acid Residue
por: Ren, Guoping, et al.
Publicado: (2009)

Arabidopsis GH3.12 (PBS3) Conjugates Amino Acids to 4-Substituted Benzoates and Is Inhibited by Salicylate
por: Okrent, Rachel A., et al.
Publicado: (2009)

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation
por: Elliott, J. Michael, et al.
Publicado: (2009)

Time-dependent Autoinactivation of Phospho-Thr(286)-αCa(2+)/Calmodulin-dependent Protein Kinase II
por: Jama, Abdirahman M., et al.
Publicado: (2009)

Structure-based Mechanism of ADP-ribosylation by Sirtuins
por: Hawse, William F., et al.
Publicado: (2009)

A Biosensor for Fluorescent Determination of ADP with High Time Resolution
por: Kunzelmann, Simone, et al.
Publicado: (2009)

Role of Bacillus subtilis BacB in the Synthesis of Bacilysin
por: Rajavel, Malligarjunan, et al.
Publicado: (2009)

Chemical Validation of Trypanothione Synthetase: A POTENTIAL DRUG TARGET FOR HUMAN TRYPANOSOMIASIS
por: Torrie, Leah S., et al.
Publicado: (2009)

Only One Protomer Is Active in the Dimer of SARS 3C-like Proteinase
por: Chen, Hao, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_4mqh7km6h512r1rnge7p2h1clu