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Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review
PURPOSE: This systematic review focused on rare histological types of corpus uteri malignancy, including uterine carcinosarcoma (UCS), uterine clear cell carcinoma (UCCC), and uterine papillary serous carcinoma (UPSC), and it is proposed to assist with clinical decision-making. Adjuvant treatment de...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060961/ https://www.ncbi.nlm.nih.gov/pubmed/33897798 http://dx.doi.org/10.5114/jcb.2021.105292 |
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author | De Felice, Francesca Lancellotta, Valentina Vicenzi, Lisa Costantini, Sara Antonacci, Alfredo Cerboneschi, Valentina di Cristino, Daniela Tagliaferri, Luca Cerrotta, Annamaria Vavassori, Andrea Gribaudo, Sergio Colombo, Alessandro Lucà, Francesco Barbara, Raffaele Mangoni, Monica Marampon, Francesco Musio, Daniela Bellati, Filippo Ruscito, Ilary Torcia, Francesco Tombolini, Vincenzo Osti, Mattia Falchetto De Sanctis, Vitaliana |
author_facet | De Felice, Francesca Lancellotta, Valentina Vicenzi, Lisa Costantini, Sara Antonacci, Alfredo Cerboneschi, Valentina di Cristino, Daniela Tagliaferri, Luca Cerrotta, Annamaria Vavassori, Andrea Gribaudo, Sergio Colombo, Alessandro Lucà, Francesco Barbara, Raffaele Mangoni, Monica Marampon, Francesco Musio, Daniela Bellati, Filippo Ruscito, Ilary Torcia, Francesco Tombolini, Vincenzo Osti, Mattia Falchetto De Sanctis, Vitaliana |
author_sort | De Felice, Francesca |
collection | PubMed |
description | PURPOSE: This systematic review focused on rare histological types of corpus uteri malignancy, including uterine carcinosarcoma (UCS), uterine clear cell carcinoma (UCCC), and uterine papillary serous carcinoma (UPSC), and it is proposed to assist with clinical decision-making. Adjuvant treatment decisions must be made based on available evidences. We mainly investigated the role of vaginal interventional radiotherapy (VIRt) in UCS, UCCC, and UPSC managements. MATERIAL AND METHODS: A systematic research using PubMed and Cochrane library was conducted to identify full articles evaluating the efficacy of VIRt in early-stage UPSC, UCCC, and UCS. A search in ClinicalTrials.gov was performed in order to detect ongoing or recently completed trials as well as in PROSPERO for ongoing or recently completed systematic reviews. Survival outcomes and toxicity rates were obtained. RESULTS: All studies were retrospective. For UCS, the number of evaluated patients was 432. The 2- to 5-year average local control (LC) was 91% (range, 74.2-96%), disease-free survival (DFS) 88% (range, 82-94%), overall survival (OS) 79% (range, 53.8-84.3%), the average 5-year cancer-specific survival (CSS) was 70% (range, 70-94%), and G3-G4 toxicity was 0%. For UCCC, the number of investigated patients was 335 (UCCC – 124, mixed – 211), with an average 5-year LC of 100%, DFS of 83% (range, 82-90%), OS of 93% (range, 83-100%), and G3-G4 toxicity of 0%. For UPSC, the number of examined patients was 1,092 (UPSC – 866, mixed – 226). The average 5-year LC was 97% (range, 87.1-100%), DFS 84% (range, 74.7-95.6%), OS 93% (range, 71.9-100%), CSS 89% (range, 78.9-94%), and G3-G4 toxicity was 0%. CONCLUSIONS: These data suggest that in adequately selected early-stage UPSC and UCCC patients, VIRt alone may be suitable in women who underwent surgical staging and received adjuvant chemotherapy. In early-stage UCS, a multidisciplinary therapeutic approach has to be planned, considering high-rate of pelvic and distant relapses. |
format | Online Article Text |
id | pubmed-8060961 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-80609612021-04-23 Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review De Felice, Francesca Lancellotta, Valentina Vicenzi, Lisa Costantini, Sara Antonacci, Alfredo Cerboneschi, Valentina di Cristino, Daniela Tagliaferri, Luca Cerrotta, Annamaria Vavassori, Andrea Gribaudo, Sergio Colombo, Alessandro Lucà, Francesco Barbara, Raffaele Mangoni, Monica Marampon, Francesco Musio, Daniela Bellati, Filippo Ruscito, Ilary Torcia, Francesco Tombolini, Vincenzo Osti, Mattia Falchetto De Sanctis, Vitaliana J Contemp Brachytherapy Review Paper PURPOSE: This systematic review focused on rare histological types of corpus uteri malignancy, including uterine carcinosarcoma (UCS), uterine clear cell carcinoma (UCCC), and uterine papillary serous carcinoma (UPSC), and it is proposed to assist with clinical decision-making. Adjuvant treatment decisions must be made based on available evidences. We mainly investigated the role of vaginal interventional radiotherapy (VIRt) in UCS, UCCC, and UPSC managements. MATERIAL AND METHODS: A systematic research using PubMed and Cochrane library was conducted to identify full articles evaluating the efficacy of VIRt in early-stage UPSC, UCCC, and UCS. A search in ClinicalTrials.gov was performed in order to detect ongoing or recently completed trials as well as in PROSPERO for ongoing or recently completed systematic reviews. Survival outcomes and toxicity rates were obtained. RESULTS: All studies were retrospective. For UCS, the number of evaluated patients was 432. The 2- to 5-year average local control (LC) was 91% (range, 74.2-96%), disease-free survival (DFS) 88% (range, 82-94%), overall survival (OS) 79% (range, 53.8-84.3%), the average 5-year cancer-specific survival (CSS) was 70% (range, 70-94%), and G3-G4 toxicity was 0%. For UCCC, the number of investigated patients was 335 (UCCC – 124, mixed – 211), with an average 5-year LC of 100%, DFS of 83% (range, 82-90%), OS of 93% (range, 83-100%), and G3-G4 toxicity of 0%. For UPSC, the number of examined patients was 1,092 (UPSC – 866, mixed – 226). The average 5-year LC was 97% (range, 87.1-100%), DFS 84% (range, 74.7-95.6%), OS 93% (range, 71.9-100%), CSS 89% (range, 78.9-94%), and G3-G4 toxicity was 0%. CONCLUSIONS: These data suggest that in adequately selected early-stage UPSC and UCCC patients, VIRt alone may be suitable in women who underwent surgical staging and received adjuvant chemotherapy. In early-stage UCS, a multidisciplinary therapeutic approach has to be planned, considering high-rate of pelvic and distant relapses. Termedia Publishing House 2021-04-14 2021-04 /pmc/articles/PMC8060961/ /pubmed/33897798 http://dx.doi.org/10.5114/jcb.2021.105292 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Review Paper De Felice, Francesca Lancellotta, Valentina Vicenzi, Lisa Costantini, Sara Antonacci, Alfredo Cerboneschi, Valentina di Cristino, Daniela Tagliaferri, Luca Cerrotta, Annamaria Vavassori, Andrea Gribaudo, Sergio Colombo, Alessandro Lucà, Francesco Barbara, Raffaele Mangoni, Monica Marampon, Francesco Musio, Daniela Bellati, Filippo Ruscito, Ilary Torcia, Francesco Tombolini, Vincenzo Osti, Mattia Falchetto De Sanctis, Vitaliana Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review |
title | Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review |
title_full | Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review |
title_fullStr | Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review |
title_full_unstemmed | Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review |
title_short | Adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review |
title_sort | adjuvant vaginal interventional radiotherapy in early-stage non-endometrioid carcinoma of corpus uteri: a systematic review |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060961/ https://www.ncbi.nlm.nih.gov/pubmed/33897798 http://dx.doi.org/10.5114/jcb.2021.105292 |
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