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A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter

Medical treatment may require the continuous intravenous (IV) infusion of drugs to sustain the therapeutic blood concentration and to minimize dosing errors. Animal disease models that ultimately mimic the intended use of new potential drugs via a continuous IV infusion in unrestrained, free roaming...

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Autores principales: Dor, Eyal, David, Tseela, Dekel Jaoui, Hani, Schwartz, Arieh, Baruchi, Tzadok, Torgeman, Amram, Ben David, Alon, Rosen, Osnat, Tal, Arnon, Rosner, Amir, Zichel, Ran, Diamant, Eran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061032/
https://www.ncbi.nlm.nih.gov/pubmed/33897426
http://dx.doi.org/10.3389/fphar.2021.637792
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author Dor, Eyal
David, Tseela
Dekel Jaoui, Hani
Schwartz, Arieh
Baruchi, Tzadok
Torgeman, Amram
Ben David, Alon
Rosen, Osnat
Tal, Arnon
Rosner, Amir
Zichel, Ran
Diamant, Eran
author_facet Dor, Eyal
David, Tseela
Dekel Jaoui, Hani
Schwartz, Arieh
Baruchi, Tzadok
Torgeman, Amram
Ben David, Alon
Rosen, Osnat
Tal, Arnon
Rosner, Amir
Zichel, Ran
Diamant, Eran
author_sort Dor, Eyal
collection PubMed
description Medical treatment may require the continuous intravenous (IV) infusion of drugs to sustain the therapeutic blood concentration and to minimize dosing errors. Animal disease models that ultimately mimic the intended use of new potential drugs via a continuous IV infusion in unrestrained, free roaming animals are required. While peripherally inserted central catheters (PICCs) and other central line techniques for prolonged IV infusion of drugs are prevalent in the clinic, continuous IV infusion methods in an animal model are challenging and limited. In most cases, continuous IV infusion methods require surgical knowledge as well as expensive and complicated equipment. In the current work, we established a novel rabbit model for prolonged continuous IV infusion by inserting a PICC line from the marginal ear vein to the superior vena cava and connecting it to an externally carried ambulatory infusion pump. Either saline or a clinically relevant formulation could be steadily and continuously infused at 3–6 ml/h for 11 consecutive days into freely moving rabbits while maintaining normal body temperature, weight, and respiration physiology, as determined by daily spirometry. This new model is simple to execute and can advance the ability to administer and test new drug candidates.
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spelling pubmed-80610322021-04-23 A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter Dor, Eyal David, Tseela Dekel Jaoui, Hani Schwartz, Arieh Baruchi, Tzadok Torgeman, Amram Ben David, Alon Rosen, Osnat Tal, Arnon Rosner, Amir Zichel, Ran Diamant, Eran Front Pharmacol Pharmacology Medical treatment may require the continuous intravenous (IV) infusion of drugs to sustain the therapeutic blood concentration and to minimize dosing errors. Animal disease models that ultimately mimic the intended use of new potential drugs via a continuous IV infusion in unrestrained, free roaming animals are required. While peripherally inserted central catheters (PICCs) and other central line techniques for prolonged IV infusion of drugs are prevalent in the clinic, continuous IV infusion methods in an animal model are challenging and limited. In most cases, continuous IV infusion methods require surgical knowledge as well as expensive and complicated equipment. In the current work, we established a novel rabbit model for prolonged continuous IV infusion by inserting a PICC line from the marginal ear vein to the superior vena cava and connecting it to an externally carried ambulatory infusion pump. Either saline or a clinically relevant formulation could be steadily and continuously infused at 3–6 ml/h for 11 consecutive days into freely moving rabbits while maintaining normal body temperature, weight, and respiration physiology, as determined by daily spirometry. This new model is simple to execute and can advance the ability to administer and test new drug candidates. Frontiers Media S.A. 2021-04-08 /pmc/articles/PMC8061032/ /pubmed/33897426 http://dx.doi.org/10.3389/fphar.2021.637792 Text en Copyright © 2021 Dor, David, Dekel Jaoui, Schwartz, Baruchi, Torgeman, Ben David, Rosen, Tal, Rosner, Zichel and Diamant. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Dor, Eyal
David, Tseela
Dekel Jaoui, Hani
Schwartz, Arieh
Baruchi, Tzadok
Torgeman, Amram
Ben David, Alon
Rosen, Osnat
Tal, Arnon
Rosner, Amir
Zichel, Ran
Diamant, Eran
A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter
title A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter
title_full A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter
title_fullStr A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter
title_full_unstemmed A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter
title_short A Rabbit Model for Prolonged Continuous Intravenous Infusion Via a Peripherally Inserted Central Catheter
title_sort rabbit model for prolonged continuous intravenous infusion via a peripherally inserted central catheter
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061032/
https://www.ncbi.nlm.nih.gov/pubmed/33897426
http://dx.doi.org/10.3389/fphar.2021.637792
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