Cargando…
Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer’s disease risk
Alzheimer’s disease (AD) is the most common type of dementia, affecting millions of people worldwide; however, no disease-modifying treatments are currently available. Genome-wide association studies (GWASs) have identified more than 40 loci associated with AD risk. However, most of the disease-asso...
Autores principales: | Novikova, Gloriia, Andrews, Shea J., Renton, Alan E., Marcora, Edoardo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061035/ https://www.ncbi.nlm.nih.gov/pubmed/33882988 http://dx.doi.org/10.1186/s13024-021-00449-0 |
Ejemplares similares
-
BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues
por: Podlesny-Drabiniok, Anna, et al.
Publicado: (2023) -
The complex genetic architecture of Alzheimer's disease: novel insights and future directions
por: Andrews, Shea J., et al.
Publicado: (2023) -
Integration of Alzheimer’s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes
por: Novikova, Gloriia, et al.
Publicado: (2021) -
Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy
por: Bhandari, Pushpak, et al.
Publicado: (2018) -
Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases
por: Kapoor, Manav, et al.
Publicado: (2021)