Assay dependence of long-term kinetics of SARS-CoV-2 antibodies

Since the worldwide outbreak of the novel coronavirus (SARS-CoV-2), the question raised whether infected patients would elicit long-lasting protective immunity. Several companies developed serological assays for the detection of SARS-CoV-2 antibodies. In this study, we compared 4 different serology...

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Autores principales: Schallier, Anneleen, De Baets, Sarah, De Bruyne, Dirk, Dauwe, Kenny, Herpol, Margaux, Couck, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061083/
https://www.ncbi.nlm.nih.gov/pubmed/34058541
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115403
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author Schallier, Anneleen
De Baets, Sarah
De Bruyne, Dirk
Dauwe, Kenny
Herpol, Margaux
Couck, Pedro
author_facet Schallier, Anneleen
De Baets, Sarah
De Bruyne, Dirk
Dauwe, Kenny
Herpol, Margaux
Couck, Pedro
author_sort Schallier, Anneleen
collection PubMed
description Since the worldwide outbreak of the novel coronavirus (SARS-CoV-2), the question raised whether infected patients would elicit long-lasting protective immunity. Several companies developed serological assays for the detection of SARS-CoV-2 antibodies. In this study, we compared 4 different serology assays in convalescents up to 7 months post-infection. Both Abbott assays showed a significative decrease of IgG antibodies over time. Whereas the Elecsys Anti‑SARS‑CoV‑2 N assay (Roche) initially showed a significant increase, antibody titers significantly decreased at the latest timepoint. Although not significant, the Elecsys Anti‑SARS‑CoV‑2 S assay (Roche) showed tendency towards increasing titers overtime. Our data showed that results of SARS-CoV-2 serology should be interpreted with caution.
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spelling pubmed-80610832021-04-22 Assay dependence of long-term kinetics of SARS-CoV-2 antibodies Schallier, Anneleen De Baets, Sarah De Bruyne, Dirk Dauwe, Kenny Herpol, Margaux Couck, Pedro Diagn Microbiol Infect Dis Article Since the worldwide outbreak of the novel coronavirus (SARS-CoV-2), the question raised whether infected patients would elicit long-lasting protective immunity. Several companies developed serological assays for the detection of SARS-CoV-2 antibodies. In this study, we compared 4 different serology assays in convalescents up to 7 months post-infection. Both Abbott assays showed a significative decrease of IgG antibodies over time. Whereas the Elecsys Anti‑SARS‑CoV‑2 N assay (Roche) initially showed a significant increase, antibody titers significantly decreased at the latest timepoint. Although not significant, the Elecsys Anti‑SARS‑CoV‑2 S assay (Roche) showed tendency towards increasing titers overtime. Our data showed that results of SARS-CoV-2 serology should be interpreted with caution. Elsevier Inc. 2021-08 2021-04-22 /pmc/articles/PMC8061083/ /pubmed/34058541 http://dx.doi.org/10.1016/j.diagmicrobio.2021.115403 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Schallier, Anneleen
De Baets, Sarah
De Bruyne, Dirk
Dauwe, Kenny
Herpol, Margaux
Couck, Pedro
Assay dependence of long-term kinetics of SARS-CoV-2 antibodies
title Assay dependence of long-term kinetics of SARS-CoV-2 antibodies
title_full Assay dependence of long-term kinetics of SARS-CoV-2 antibodies
title_fullStr Assay dependence of long-term kinetics of SARS-CoV-2 antibodies
title_full_unstemmed Assay dependence of long-term kinetics of SARS-CoV-2 antibodies
title_short Assay dependence of long-term kinetics of SARS-CoV-2 antibodies
title_sort assay dependence of long-term kinetics of sars-cov-2 antibodies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061083/
https://www.ncbi.nlm.nih.gov/pubmed/34058541
http://dx.doi.org/10.1016/j.diagmicrobio.2021.115403
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