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Role of masks, testing and contact tracing in preventing COVID-19 resurgences: a case study from New South Wales, Australia

OBJECTIVES: The early stages of the COVID-19 pandemic illustrated that SARS-CoV-2, the virus that causes the disease, has the potential to spread exponentially. Therefore, as long as a substantial proportion of the population remains susceptible to infection, the potential for new epidemic waves per...

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Autores principales: Stuart, Robyn M, Abeysuriya, Romesh G, Kerr, Cliff C, Mistry, Dina, Klein, Dan J, Gray, Richard T, Hellard, Margaret, Scott, Nick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061569/
https://www.ncbi.nlm.nih.gov/pubmed/33879491
http://dx.doi.org/10.1136/bmjopen-2020-045941
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author Stuart, Robyn M
Abeysuriya, Romesh G
Kerr, Cliff C
Mistry, Dina
Klein, Dan J
Gray, Richard T
Hellard, Margaret
Scott, Nick
author_facet Stuart, Robyn M
Abeysuriya, Romesh G
Kerr, Cliff C
Mistry, Dina
Klein, Dan J
Gray, Richard T
Hellard, Margaret
Scott, Nick
author_sort Stuart, Robyn M
collection PubMed
description OBJECTIVES: The early stages of the COVID-19 pandemic illustrated that SARS-CoV-2, the virus that causes the disease, has the potential to spread exponentially. Therefore, as long as a substantial proportion of the population remains susceptible to infection, the potential for new epidemic waves persists even in settings with low numbers of active COVID-19 infections, unless sufficient countermeasures are in place. We aim to quantify vulnerability to resurgences in COVID-19 transmission under variations in the levels of testing, tracing and mask usage. SETTING: The Australian state of New South Wales (NSW), a setting with prolonged low transmission, high mobility, non-universal mask usage and a well-functioning test-and-trace system. PARTICIPANTS: None (simulation study). RESULTS: We find that the relative impact of masks is greatest when testing and tracing rates are lower and vice versa. Scenarios with very high testing rates (90% of people with symptoms, plus 90% of people with a known history of contact with a confirmed case) were estimated to lead to a robustly controlled epidemic. However, across comparable levels of mask uptake and contact tracing, the number of infections over this period was projected to be 2–3 times higher if the testing rate was 80% instead of 90%, 8–12 times higher if the testing rate was 65% or 30–50 times higher with a 50% testing rate. In reality, NSW diagnosed 254 locally acquired cases over this period, an outcome that had a moderate probability in the model (10%–18%) assuming low mask uptake (0%–25%), even in the presence of extremely high testing (90%) and near-perfect community contact tracing (75%–100%), and a considerably higher probability if testing or tracing were at lower levels. CONCLUSIONS: Our work suggests that testing, tracing and masks can all be effective means of controlling transmission. A multifaceted strategy that combines all three, alongside continued hygiene and distancing protocols, is likely to be the most robust means of controlling transmission of SARS-CoV-2.
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spelling pubmed-80615692021-04-22 Role of masks, testing and contact tracing in preventing COVID-19 resurgences: a case study from New South Wales, Australia Stuart, Robyn M Abeysuriya, Romesh G Kerr, Cliff C Mistry, Dina Klein, Dan J Gray, Richard T Hellard, Margaret Scott, Nick BMJ Open Epidemiology OBJECTIVES: The early stages of the COVID-19 pandemic illustrated that SARS-CoV-2, the virus that causes the disease, has the potential to spread exponentially. Therefore, as long as a substantial proportion of the population remains susceptible to infection, the potential for new epidemic waves persists even in settings with low numbers of active COVID-19 infections, unless sufficient countermeasures are in place. We aim to quantify vulnerability to resurgences in COVID-19 transmission under variations in the levels of testing, tracing and mask usage. SETTING: The Australian state of New South Wales (NSW), a setting with prolonged low transmission, high mobility, non-universal mask usage and a well-functioning test-and-trace system. PARTICIPANTS: None (simulation study). RESULTS: We find that the relative impact of masks is greatest when testing and tracing rates are lower and vice versa. Scenarios with very high testing rates (90% of people with symptoms, plus 90% of people with a known history of contact with a confirmed case) were estimated to lead to a robustly controlled epidemic. However, across comparable levels of mask uptake and contact tracing, the number of infections over this period was projected to be 2–3 times higher if the testing rate was 80% instead of 90%, 8–12 times higher if the testing rate was 65% or 30–50 times higher with a 50% testing rate. In reality, NSW diagnosed 254 locally acquired cases over this period, an outcome that had a moderate probability in the model (10%–18%) assuming low mask uptake (0%–25%), even in the presence of extremely high testing (90%) and near-perfect community contact tracing (75%–100%), and a considerably higher probability if testing or tracing were at lower levels. CONCLUSIONS: Our work suggests that testing, tracing and masks can all be effective means of controlling transmission. A multifaceted strategy that combines all three, alongside continued hygiene and distancing protocols, is likely to be the most robust means of controlling transmission of SARS-CoV-2. BMJ Publishing Group 2021-04-20 /pmc/articles/PMC8061569/ /pubmed/33879491 http://dx.doi.org/10.1136/bmjopen-2020-045941 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Epidemiology
Stuart, Robyn M
Abeysuriya, Romesh G
Kerr, Cliff C
Mistry, Dina
Klein, Dan J
Gray, Richard T
Hellard, Margaret
Scott, Nick
Role of masks, testing and contact tracing in preventing COVID-19 resurgences: a case study from New South Wales, Australia
title Role of masks, testing and contact tracing in preventing COVID-19 resurgences: a case study from New South Wales, Australia
title_full Role of masks, testing and contact tracing in preventing COVID-19 resurgences: a case study from New South Wales, Australia
title_fullStr Role of masks, testing and contact tracing in preventing COVID-19 resurgences: a case study from New South Wales, Australia
title_full_unstemmed Role of masks, testing and contact tracing in preventing COVID-19 resurgences: a case study from New South Wales, Australia
title_short Role of masks, testing and contact tracing in preventing COVID-19 resurgences: a case study from New South Wales, Australia
title_sort role of masks, testing and contact tracing in preventing covid-19 resurgences: a case study from new south wales, australia
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061569/
https://www.ncbi.nlm.nih.gov/pubmed/33879491
http://dx.doi.org/10.1136/bmjopen-2020-045941
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