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Testing for non-inferior mortality: a systematic review of non-inferiority margin sizes and trial characteristics

OBJECTIVE: To describe the size and variability of non-inferiority margins used in non-inferiority trials of medications with primary outcomes involving mortality, and to examine the association between trial characteristics and non-inferiority margin size. DESIGN: Systematic review. DATA SOURCES: M...

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Detalles Bibliográficos
Autores principales:	Pong, Sandra, Urner, Martin, Fowler, Robert A, Mitsakakis, Nicholas, Seto, Winnie, Hutchison, James S, Science, Michelle, Daneman, Nick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Research Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061825/ https://www.ncbi.nlm.nih.gov/pubmed/33879485 http://dx.doi.org/10.1136/bmjopen-2020-044480

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