Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis

BACKGROUND: Numerous trials combining radiation therapy (RT) and immunotherapy in head and neck squamous cell carcinoma (HNSCC) are failing. Using preclinical immune cold models of HNSCC resistant to RT-immune checkpoint inhibitors, we investigate therapeutic approaches of overcoming such resistance...

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Detalles Bibliográficos
Autores principales: Knitz, Michael W, Bickett, Thomas E, Darragh, Laurel B, Oweida, Ayman J, Bhatia, Shilpa, Van Court, Benjamin, Bhuvane, Shiv, Piper, Miles, Gadwa, Jacob, Mueller, Adam C, Nguyen, Diemmy, Nangia, Varuna, Osborne, Douglas G, Bai, Xiyuan, Ferrara, Sarah E, Boss, Mary-Keara, Goodspeed, Andrew, Burchill, Matthew A, Tamburini, Beth A Jirón, Chan, Edward D, Pickering, Curtis R, Clambey, Eric T, Karam, Sana D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061827/
https://www.ncbi.nlm.nih.gov/pubmed/33883256
http://dx.doi.org/10.1136/jitc-2020-001955

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