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Actives from MMV Open Access Boxes? A suggested way forward

It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug disc...

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Autores principales: Samby, Kirandeep, Willis, Paul A., Burrows, Jeremy N., Laleu, Benoît, Webborn, Peter J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061869/
https://www.ncbi.nlm.nih.gov/pubmed/33886696
http://dx.doi.org/10.1371/journal.ppat.1009384
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author Samby, Kirandeep
Willis, Paul A.
Burrows, Jeremy N.
Laleu, Benoît
Webborn, Peter J. H.
author_facet Samby, Kirandeep
Willis, Paul A.
Burrows, Jeremy N.
Laleu, Benoît
Webborn, Peter J. H.
author_sort Samby, Kirandeep
collection PubMed
description It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug discovery efforts are required to reduce the burden of these diseases in endemic regions. The release of “Open Access Boxes” is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. These boxes are mainly requested by biology researchers across the globe who may not otherwise have access to compounds to screen nor knowledge of the workflow that needs to be followed after identification of actives from their screening campaigns. Here, we present guidelines on how to move such actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative.
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spelling pubmed-80618692021-05-04 Actives from MMV Open Access Boxes? A suggested way forward Samby, Kirandeep Willis, Paul A. Burrows, Jeremy N. Laleu, Benoît Webborn, Peter J. H. PLoS Pathog Review It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug discovery efforts are required to reduce the burden of these diseases in endemic regions. The release of “Open Access Boxes” is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. These boxes are mainly requested by biology researchers across the globe who may not otherwise have access to compounds to screen nor knowledge of the workflow that needs to be followed after identification of actives from their screening campaigns. Here, we present guidelines on how to move such actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative. Public Library of Science 2021-04-22 /pmc/articles/PMC8061869/ /pubmed/33886696 http://dx.doi.org/10.1371/journal.ppat.1009384 Text en © 2021 Samby et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Samby, Kirandeep
Willis, Paul A.
Burrows, Jeremy N.
Laleu, Benoît
Webborn, Peter J. H.
Actives from MMV Open Access Boxes? A suggested way forward
title Actives from MMV Open Access Boxes? A suggested way forward
title_full Actives from MMV Open Access Boxes? A suggested way forward
title_fullStr Actives from MMV Open Access Boxes? A suggested way forward
title_full_unstemmed Actives from MMV Open Access Boxes? A suggested way forward
title_short Actives from MMV Open Access Boxes? A suggested way forward
title_sort actives from mmv open access boxes? a suggested way forward
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061869/
https://www.ncbi.nlm.nih.gov/pubmed/33886696
http://dx.doi.org/10.1371/journal.ppat.1009384
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