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Actives from MMV Open Access Boxes? A suggested way forward
It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug disc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061869/ https://www.ncbi.nlm.nih.gov/pubmed/33886696 http://dx.doi.org/10.1371/journal.ppat.1009384 |
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author | Samby, Kirandeep Willis, Paul A. Burrows, Jeremy N. Laleu, Benoît Webborn, Peter J. H. |
author_facet | Samby, Kirandeep Willis, Paul A. Burrows, Jeremy N. Laleu, Benoît Webborn, Peter J. H. |
author_sort | Samby, Kirandeep |
collection | PubMed |
description | It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug discovery efforts are required to reduce the burden of these diseases in endemic regions. The release of “Open Access Boxes” is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. These boxes are mainly requested by biology researchers across the globe who may not otherwise have access to compounds to screen nor knowledge of the workflow that needs to be followed after identification of actives from their screening campaigns. Here, we present guidelines on how to move such actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative. |
format | Online Article Text |
id | pubmed-8061869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80618692021-05-04 Actives from MMV Open Access Boxes? A suggested way forward Samby, Kirandeep Willis, Paul A. Burrows, Jeremy N. Laleu, Benoît Webborn, Peter J. H. PLoS Pathog Review It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug discovery efforts are required to reduce the burden of these diseases in endemic regions. The release of “Open Access Boxes” is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. These boxes are mainly requested by biology researchers across the globe who may not otherwise have access to compounds to screen nor knowledge of the workflow that needs to be followed after identification of actives from their screening campaigns. Here, we present guidelines on how to move such actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative. Public Library of Science 2021-04-22 /pmc/articles/PMC8061869/ /pubmed/33886696 http://dx.doi.org/10.1371/journal.ppat.1009384 Text en © 2021 Samby et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Samby, Kirandeep Willis, Paul A. Burrows, Jeremy N. Laleu, Benoît Webborn, Peter J. H. Actives from MMV Open Access Boxes? A suggested way forward |
title | Actives from MMV Open Access Boxes? A suggested way forward |
title_full | Actives from MMV Open Access Boxes? A suggested way forward |
title_fullStr | Actives from MMV Open Access Boxes? A suggested way forward |
title_full_unstemmed | Actives from MMV Open Access Boxes? A suggested way forward |
title_short | Actives from MMV Open Access Boxes? A suggested way forward |
title_sort | actives from mmv open access boxes? a suggested way forward |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061869/ https://www.ncbi.nlm.nih.gov/pubmed/33886696 http://dx.doi.org/10.1371/journal.ppat.1009384 |
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