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Impact of electric cardioversion on platelet activation

INTRODUCTION: Atrial fibrillation (AF) comes along with high risk of stroke. This risk continues even after re-establishing sinus rhythm with cardioversion. Aim of this study is to evaluate the contribution of electric cardioversion (EC) to platelet activation and procoagulatory tendency. METHODS: E...

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Autores principales: Haidl, Harald, Gaugler, Johanna, Cvirn, Gerhard, Jasser-Nitsche, Hildegard, Schwinger, Wolfgang, Pohl, Sina, Bisping, Egbert, Gallistl, Siegfried, Schlagenhauf, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061933/
https://www.ncbi.nlm.nih.gov/pubmed/33886660
http://dx.doi.org/10.1371/journal.pone.0250353
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author Haidl, Harald
Gaugler, Johanna
Cvirn, Gerhard
Jasser-Nitsche, Hildegard
Schwinger, Wolfgang
Pohl, Sina
Bisping, Egbert
Gallistl, Siegfried
Schlagenhauf, Axel
author_facet Haidl, Harald
Gaugler, Johanna
Cvirn, Gerhard
Jasser-Nitsche, Hildegard
Schwinger, Wolfgang
Pohl, Sina
Bisping, Egbert
Gallistl, Siegfried
Schlagenhauf, Axel
author_sort Haidl, Harald
collection PubMed
description INTRODUCTION: Atrial fibrillation (AF) comes along with high risk of stroke. This risk continues even after re-establishing sinus rhythm with cardioversion. Aim of this study is to evaluate the contribution of electric cardioversion (EC) to platelet activation and procoagulatory tendency. METHODS: Extent of platelet activation before and after electric cardioversion was quantified using flow cytometry, impedance aggregation measurements with Multiplate®, and quantification of serum levels of platelet factor 4 (PF4) and ß-thromboglobulin (ß-TG) in patients with AF (N = 10). RESULTS: No significant differences were observed in any of the measured parameters comparing the values from before and after cardioversion. Geometric means of P-selectin expression and integrin αIIbβ3 activation were 0.27 (+/- 0.07) and 2.30 (+/- 2.61) before EC and 0.28 (+/- 0.17) and 1.67 (+/- 1.82) after EC. Levels of ß-TG were 110.11 ng/ml (+/- 3.78) before and 110.51 ng/ml (+/- 2.56) after EC, levels of PF4 were 35.64 ng/ml (+/- 12.94) before and 32.40 ng/ml (+/- 4.95) after EC. Platelet aggregation triggered with adenosine diphosphate (ADP), arachidonic acid, collagen, Ristocetin, or thrombin receptor activating peptide (TRAP) revealed results within the normally expected ranges without significant changes before and after EC. DISCUSSION: Electric cardioversion has no influence on platelet activation markers which is in agreement with other studies reporting electrical cardioversion to be safe.
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spelling pubmed-80619332021-05-04 Impact of electric cardioversion on platelet activation Haidl, Harald Gaugler, Johanna Cvirn, Gerhard Jasser-Nitsche, Hildegard Schwinger, Wolfgang Pohl, Sina Bisping, Egbert Gallistl, Siegfried Schlagenhauf, Axel PLoS One Research Article INTRODUCTION: Atrial fibrillation (AF) comes along with high risk of stroke. This risk continues even after re-establishing sinus rhythm with cardioversion. Aim of this study is to evaluate the contribution of electric cardioversion (EC) to platelet activation and procoagulatory tendency. METHODS: Extent of platelet activation before and after electric cardioversion was quantified using flow cytometry, impedance aggregation measurements with Multiplate®, and quantification of serum levels of platelet factor 4 (PF4) and ß-thromboglobulin (ß-TG) in patients with AF (N = 10). RESULTS: No significant differences were observed in any of the measured parameters comparing the values from before and after cardioversion. Geometric means of P-selectin expression and integrin αIIbβ3 activation were 0.27 (+/- 0.07) and 2.30 (+/- 2.61) before EC and 0.28 (+/- 0.17) and 1.67 (+/- 1.82) after EC. Levels of ß-TG were 110.11 ng/ml (+/- 3.78) before and 110.51 ng/ml (+/- 2.56) after EC, levels of PF4 were 35.64 ng/ml (+/- 12.94) before and 32.40 ng/ml (+/- 4.95) after EC. Platelet aggregation triggered with adenosine diphosphate (ADP), arachidonic acid, collagen, Ristocetin, or thrombin receptor activating peptide (TRAP) revealed results within the normally expected ranges without significant changes before and after EC. DISCUSSION: Electric cardioversion has no influence on platelet activation markers which is in agreement with other studies reporting electrical cardioversion to be safe. Public Library of Science 2021-04-22 /pmc/articles/PMC8061933/ /pubmed/33886660 http://dx.doi.org/10.1371/journal.pone.0250353 Text en © 2021 Haidl et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Haidl, Harald
Gaugler, Johanna
Cvirn, Gerhard
Jasser-Nitsche, Hildegard
Schwinger, Wolfgang
Pohl, Sina
Bisping, Egbert
Gallistl, Siegfried
Schlagenhauf, Axel
Impact of electric cardioversion on platelet activation
title Impact of electric cardioversion on platelet activation
title_full Impact of electric cardioversion on platelet activation
title_fullStr Impact of electric cardioversion on platelet activation
title_full_unstemmed Impact of electric cardioversion on platelet activation
title_short Impact of electric cardioversion on platelet activation
title_sort impact of electric cardioversion on platelet activation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061933/
https://www.ncbi.nlm.nih.gov/pubmed/33886660
http://dx.doi.org/10.1371/journal.pone.0250353
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