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Impact of electric cardioversion on platelet activation
INTRODUCTION: Atrial fibrillation (AF) comes along with high risk of stroke. This risk continues even after re-establishing sinus rhythm with cardioversion. Aim of this study is to evaluate the contribution of electric cardioversion (EC) to platelet activation and procoagulatory tendency. METHODS: E...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061933/ https://www.ncbi.nlm.nih.gov/pubmed/33886660 http://dx.doi.org/10.1371/journal.pone.0250353 |
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author | Haidl, Harald Gaugler, Johanna Cvirn, Gerhard Jasser-Nitsche, Hildegard Schwinger, Wolfgang Pohl, Sina Bisping, Egbert Gallistl, Siegfried Schlagenhauf, Axel |
author_facet | Haidl, Harald Gaugler, Johanna Cvirn, Gerhard Jasser-Nitsche, Hildegard Schwinger, Wolfgang Pohl, Sina Bisping, Egbert Gallistl, Siegfried Schlagenhauf, Axel |
author_sort | Haidl, Harald |
collection | PubMed |
description | INTRODUCTION: Atrial fibrillation (AF) comes along with high risk of stroke. This risk continues even after re-establishing sinus rhythm with cardioversion. Aim of this study is to evaluate the contribution of electric cardioversion (EC) to platelet activation and procoagulatory tendency. METHODS: Extent of platelet activation before and after electric cardioversion was quantified using flow cytometry, impedance aggregation measurements with Multiplate®, and quantification of serum levels of platelet factor 4 (PF4) and ß-thromboglobulin (ß-TG) in patients with AF (N = 10). RESULTS: No significant differences were observed in any of the measured parameters comparing the values from before and after cardioversion. Geometric means of P-selectin expression and integrin αIIbβ3 activation were 0.27 (+/- 0.07) and 2.30 (+/- 2.61) before EC and 0.28 (+/- 0.17) and 1.67 (+/- 1.82) after EC. Levels of ß-TG were 110.11 ng/ml (+/- 3.78) before and 110.51 ng/ml (+/- 2.56) after EC, levels of PF4 were 35.64 ng/ml (+/- 12.94) before and 32.40 ng/ml (+/- 4.95) after EC. Platelet aggregation triggered with adenosine diphosphate (ADP), arachidonic acid, collagen, Ristocetin, or thrombin receptor activating peptide (TRAP) revealed results within the normally expected ranges without significant changes before and after EC. DISCUSSION: Electric cardioversion has no influence on platelet activation markers which is in agreement with other studies reporting electrical cardioversion to be safe. |
format | Online Article Text |
id | pubmed-8061933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80619332021-05-04 Impact of electric cardioversion on platelet activation Haidl, Harald Gaugler, Johanna Cvirn, Gerhard Jasser-Nitsche, Hildegard Schwinger, Wolfgang Pohl, Sina Bisping, Egbert Gallistl, Siegfried Schlagenhauf, Axel PLoS One Research Article INTRODUCTION: Atrial fibrillation (AF) comes along with high risk of stroke. This risk continues even after re-establishing sinus rhythm with cardioversion. Aim of this study is to evaluate the contribution of electric cardioversion (EC) to platelet activation and procoagulatory tendency. METHODS: Extent of platelet activation before and after electric cardioversion was quantified using flow cytometry, impedance aggregation measurements with Multiplate®, and quantification of serum levels of platelet factor 4 (PF4) and ß-thromboglobulin (ß-TG) in patients with AF (N = 10). RESULTS: No significant differences were observed in any of the measured parameters comparing the values from before and after cardioversion. Geometric means of P-selectin expression and integrin αIIbβ3 activation were 0.27 (+/- 0.07) and 2.30 (+/- 2.61) before EC and 0.28 (+/- 0.17) and 1.67 (+/- 1.82) after EC. Levels of ß-TG were 110.11 ng/ml (+/- 3.78) before and 110.51 ng/ml (+/- 2.56) after EC, levels of PF4 were 35.64 ng/ml (+/- 12.94) before and 32.40 ng/ml (+/- 4.95) after EC. Platelet aggregation triggered with adenosine diphosphate (ADP), arachidonic acid, collagen, Ristocetin, or thrombin receptor activating peptide (TRAP) revealed results within the normally expected ranges without significant changes before and after EC. DISCUSSION: Electric cardioversion has no influence on platelet activation markers which is in agreement with other studies reporting electrical cardioversion to be safe. Public Library of Science 2021-04-22 /pmc/articles/PMC8061933/ /pubmed/33886660 http://dx.doi.org/10.1371/journal.pone.0250353 Text en © 2021 Haidl et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Haidl, Harald Gaugler, Johanna Cvirn, Gerhard Jasser-Nitsche, Hildegard Schwinger, Wolfgang Pohl, Sina Bisping, Egbert Gallistl, Siegfried Schlagenhauf, Axel Impact of electric cardioversion on platelet activation |
title | Impact of electric cardioversion on platelet activation |
title_full | Impact of electric cardioversion on platelet activation |
title_fullStr | Impact of electric cardioversion on platelet activation |
title_full_unstemmed | Impact of electric cardioversion on platelet activation |
title_short | Impact of electric cardioversion on platelet activation |
title_sort | impact of electric cardioversion on platelet activation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8061933/ https://www.ncbi.nlm.nih.gov/pubmed/33886660 http://dx.doi.org/10.1371/journal.pone.0250353 |
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