Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome

MicroRNA-target networks are often dysregulated in diseases. Our purpose is to investigate this dysregulation of polycystic ovary syndrome (PCOS). Through the bioinformatics reanalysis of the public RNAseq dataset, we found that miR-188-3p was the miRNA with the highest induction rate, and indicated...

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Detalles Bibliográficos
Autores principales: Dai, Beibei, Jiang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062204/
https://www.ncbi.nlm.nih.gov/pubmed/33953792
http://dx.doi.org/10.1155/2021/5587412
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author Dai, Beibei
Jiang, Jun
author_facet Dai, Beibei
Jiang, Jun
author_sort Dai, Beibei
collection PubMed
description MicroRNA-target networks are often dysregulated in diseases. Our purpose is to investigate this dysregulation of polycystic ovary syndrome (PCOS). Through the bioinformatics reanalysis of the public RNAseq dataset, we found that miR-188-3p was the miRNA with the highest induction rate, and indicated that miR-188-3p might have a rare function of upregulating its targeted expression. This discovery will increase our understanding of the pathology of PCOS and provide new targets for treatment strategies.
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spelling pubmed-80622042021-05-04 Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome Dai, Beibei Jiang, Jun Comput Math Methods Med Research Article MicroRNA-target networks are often dysregulated in diseases. Our purpose is to investigate this dysregulation of polycystic ovary syndrome (PCOS). Through the bioinformatics reanalysis of the public RNAseq dataset, we found that miR-188-3p was the miRNA with the highest induction rate, and indicated that miR-188-3p might have a rare function of upregulating its targeted expression. This discovery will increase our understanding of the pathology of PCOS and provide new targets for treatment strategies. Hindawi 2021-04-15 /pmc/articles/PMC8062204/ /pubmed/33953792 http://dx.doi.org/10.1155/2021/5587412 Text en Copyright © 2021 Beibei Dai and Jun Jiang. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dai, Beibei
Jiang, Jun
Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome
title Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome
title_full Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome
title_fullStr Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome
title_full_unstemmed Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome
title_short Increased miR-188-3p in Ovarian Granulosa Cells of Patients with Polycystic Ovary Syndrome
title_sort increased mir-188-3p in ovarian granulosa cells of patients with polycystic ovary syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062204/
https://www.ncbi.nlm.nih.gov/pubmed/33953792
http://dx.doi.org/10.1155/2021/5587412
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