The age of adult pilocytic astrocytoma cells

Adult pilocytic astrocytomas (PAs) have been regarded as indistinguishable from pediatric PAs in terms of genome-wide expression and methylation patterns. It has been unclear whether adult PAs arise early in life and remain asymptomatic until adulthood, or whether they develop during adulthood. We s...

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Autores principales: Voronina, Natalia, Aichmüller, Christian, Kolb, Thorsten, Korshunov, Andrey, Ryzhova, Marina, Barnholtz-Sloan, Jill, Cioffi, Gino, Sill, Martin, von Deimling, Andreas, Pfister, Stefan M., Gronych, Jan, Jones, David T. W., Frisén, Jonas, Zapatka, Marc, Ernst, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062266/
https://www.ncbi.nlm.nih.gov/pubmed/33731860
http://dx.doi.org/10.1038/s41388-021-01738-0
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author Voronina, Natalia
Aichmüller, Christian
Kolb, Thorsten
Korshunov, Andrey
Ryzhova, Marina
Barnholtz-Sloan, Jill
Cioffi, Gino
Sill, Martin
von Deimling, Andreas
Pfister, Stefan M.
Gronych, Jan
Jones, David T. W.
Frisén, Jonas
Zapatka, Marc
Ernst, Aurélie
author_facet Voronina, Natalia
Aichmüller, Christian
Kolb, Thorsten
Korshunov, Andrey
Ryzhova, Marina
Barnholtz-Sloan, Jill
Cioffi, Gino
Sill, Martin
von Deimling, Andreas
Pfister, Stefan M.
Gronych, Jan
Jones, David T. W.
Frisén, Jonas
Zapatka, Marc
Ernst, Aurélie
author_sort Voronina, Natalia
collection PubMed
description Adult pilocytic astrocytomas (PAs) have been regarded as indistinguishable from pediatric PAs in terms of genome-wide expression and methylation patterns. It has been unclear whether adult PAs arise early in life and remain asymptomatic until adulthood, or whether they develop during adulthood. We sought to determine the age and origin of adult human PAs using two types of “marks” in the genomic DNA. First, we analyzed the DNA methylation patterns of adult and pediatric PAs to distinguish between PAs of different anatomic locations (n = 257 PA and control brain tissues). Second, we measured the concentration of nuclear bomb test-derived (14)C in genomic DNA (n = 14 cases), which indicates the time point of the formation of human cell populations. Our data suggest that adult and pediatric PAs developing in the infratentorial brain are closely related and potentially develop from precursor cells early in life, whereas supratentorial PAs might show age and location-specific differences.
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spelling pubmed-80622662021-05-05 The age of adult pilocytic astrocytoma cells Voronina, Natalia Aichmüller, Christian Kolb, Thorsten Korshunov, Andrey Ryzhova, Marina Barnholtz-Sloan, Jill Cioffi, Gino Sill, Martin von Deimling, Andreas Pfister, Stefan M. Gronych, Jan Jones, David T. W. Frisén, Jonas Zapatka, Marc Ernst, Aurélie Oncogene Article Adult pilocytic astrocytomas (PAs) have been regarded as indistinguishable from pediatric PAs in terms of genome-wide expression and methylation patterns. It has been unclear whether adult PAs arise early in life and remain asymptomatic until adulthood, or whether they develop during adulthood. We sought to determine the age and origin of adult human PAs using two types of “marks” in the genomic DNA. First, we analyzed the DNA methylation patterns of adult and pediatric PAs to distinguish between PAs of different anatomic locations (n = 257 PA and control brain tissues). Second, we measured the concentration of nuclear bomb test-derived (14)C in genomic DNA (n = 14 cases), which indicates the time point of the formation of human cell populations. Our data suggest that adult and pediatric PAs developing in the infratentorial brain are closely related and potentially develop from precursor cells early in life, whereas supratentorial PAs might show age and location-specific differences. Nature Publishing Group UK 2021-03-17 2021 /pmc/articles/PMC8062266/ /pubmed/33731860 http://dx.doi.org/10.1038/s41388-021-01738-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Voronina, Natalia
Aichmüller, Christian
Kolb, Thorsten
Korshunov, Andrey
Ryzhova, Marina
Barnholtz-Sloan, Jill
Cioffi, Gino
Sill, Martin
von Deimling, Andreas
Pfister, Stefan M.
Gronych, Jan
Jones, David T. W.
Frisén, Jonas
Zapatka, Marc
Ernst, Aurélie
The age of adult pilocytic astrocytoma cells
title The age of adult pilocytic astrocytoma cells
title_full The age of adult pilocytic astrocytoma cells
title_fullStr The age of adult pilocytic astrocytoma cells
title_full_unstemmed The age of adult pilocytic astrocytoma cells
title_short The age of adult pilocytic astrocytoma cells
title_sort age of adult pilocytic astrocytoma cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062266/
https://www.ncbi.nlm.nih.gov/pubmed/33731860
http://dx.doi.org/10.1038/s41388-021-01738-0
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