Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. Instead, systemic therapy is typically restricted to cytotoxic chemotherapy, which fails more often in patients with elevated circulating cholesterol. Liver x receptors are ligand-depen...

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Detalles Bibliográficos
Autores principales: Hutchinson, Samantha A., Websdale, Alex, Cioccoloni, Giorgia, Røberg-Larsen, Hanne, Lianto, Priscilia, Kim, Baek, Rose, Ailsa, Soteriou, Chrysa, Pramanik, Arindam, Wastall, Laura M., Williams, Bethany J., Henn, Madeline A., Chen, Joy J., Ma, Liqian, Moore, J. Bernadette, Nelson, Erik, Hughes, Thomas A., Thorne, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062267/
https://www.ncbi.nlm.nih.gov/pubmed/33742124
http://dx.doi.org/10.1038/s41388-021-01720-w

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