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J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging
J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracycloph...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062432/ https://www.ncbi.nlm.nih.gov/pubmed/33888714 http://dx.doi.org/10.1038/s41467-021-22686-z |
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author | Li, Kang Duan, Xingchen Jiang, Zhiyong Ding, Dan Chen, Yuncong Zhang, Guo-Qiang Liu, Zhipeng |
author_facet | Li, Kang Duan, Xingchen Jiang, Zhiyong Ding, Dan Chen, Yuncong Zhang, Guo-Qiang Liu, Zhipeng |
author_sort | Li, Kang |
collection | PubMed |
description | J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-infrared fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophysical properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-infrared imaging agents. |
format | Online Article Text |
id | pubmed-8062432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80624322021-05-11 J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging Li, Kang Duan, Xingchen Jiang, Zhiyong Ding, Dan Chen, Yuncong Zhang, Guo-Qiang Liu, Zhipeng Nat Commun Article J-aggregation is an efficient strategy for the development of fluorescent imaging agents in the second near-infrared window. However, the design of the second near-infrared fluorescent J-aggregates is challenging due to the lack of suitable J-aggregation dyes. Herein, we report meso-[2.2]paracyclophanyl-3,5-bis-N,N-dimethylaminostyrl BODIPY (PCP-BDP2) as an example of BODIPY dye with J-aggregation induced the second near-infrared fluorescence. PCP-BDP2 shows an emission maximum at 1010 nm in the J-aggregation state. Mechanism studies reveal that the steric and conjugation effect of the PCP group on the BODIPY play key roles in the J-aggregation behavior and photophysical properties tuning. Notably, PCP-BDP2 J-aggregates can be utilized for lymph node imaging and fluorescence-guided surgery in the nude mouse, which demonstrates their potential clinical application. This study demonstrates BODIPY dye as an alternate J-aggregation platform for developing the second near-infrared imaging agents. Nature Publishing Group UK 2021-04-22 /pmc/articles/PMC8062432/ /pubmed/33888714 http://dx.doi.org/10.1038/s41467-021-22686-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Kang Duan, Xingchen Jiang, Zhiyong Ding, Dan Chen, Yuncong Zhang, Guo-Qiang Liu, Zhipeng J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging |
title | J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging |
title_full | J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging |
title_fullStr | J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging |
title_full_unstemmed | J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging |
title_short | J-aggregates of meso-[2.2]paracyclophanyl-BODIPY dye for NIR-II imaging |
title_sort | j-aggregates of meso-[2.2]paracyclophanyl-bodipy dye for nir-ii imaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062432/ https://www.ncbi.nlm.nih.gov/pubmed/33888714 http://dx.doi.org/10.1038/s41467-021-22686-z |
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