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Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor

This study aimed to investigate the nutricosmetic effect of Asparagus officinalis extracts. The tip and spear of A. officinalis were successively extracted with 95% ethanol. The rutin, phenolic, and flavonoid contents of A. officinalis extracts were investigated. The antioxidant activities were dete...

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Autores principales: Sriyab, Suwannee, Laosirisathian, Nachtharinee, Punyoyai, Chanun, Anuchapreeda, Songyot, Tima, Singkome, Chiampanichayakul, Sawitree, Chaiyana, Wantida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062454/
https://www.ncbi.nlm.nih.gov/pubmed/33888836
http://dx.doi.org/10.1038/s41598-021-88340-2
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author Sriyab, Suwannee
Laosirisathian, Nachtharinee
Punyoyai, Chanun
Anuchapreeda, Songyot
Tima, Singkome
Chiampanichayakul, Sawitree
Chaiyana, Wantida
author_facet Sriyab, Suwannee
Laosirisathian, Nachtharinee
Punyoyai, Chanun
Anuchapreeda, Songyot
Tima, Singkome
Chiampanichayakul, Sawitree
Chaiyana, Wantida
author_sort Sriyab, Suwannee
collection PubMed
description This study aimed to investigate the nutricosmetic effect of Asparagus officinalis extracts. The tip and spear of A. officinalis were successively extracted with 95% ethanol. The rutin, phenolic, and flavonoid contents of A. officinalis extracts were investigated. The antioxidant activities were determined by 2,2-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) and a ferric reducing antioxidant power assay. Matrix metalloproteinase-1 (MMP-1), elastase, and hyaluronidase inhibition were determined by in vitro enzyme reaction assay. The cytotoxicity was analyzed on peripheral blood mononuclear cellss. Findings revealed that drying temperature and drying duration had significant effects on the chemical composition and biological activity of A. officinalis extract. A. officinalis tips dried at 50 °C for 24 h contained the (significantly) highest flavonoid and rutin content. The most potent extract was from A. officinalis spears since it possessed the (significantly) highest MMP-1, elastase, and hyaluronidase inhibition rates of 83.4 ± 1.5%, 70.4 ± 4.1%, and 75.2 ± 1.0%, respectively. Interestingly, at the same concentration, the A. officinalis spear extract was more potent in MMP-1 inhibition than oleanolic acid and epigallocatechin gallate, the well-known natural MMP-1 inhibitors. The results show that A. officinalis extract is an attractive source of natural anti-skin-wrinkle ingredients.
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spelling pubmed-80624542021-04-23 Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor Sriyab, Suwannee Laosirisathian, Nachtharinee Punyoyai, Chanun Anuchapreeda, Songyot Tima, Singkome Chiampanichayakul, Sawitree Chaiyana, Wantida Sci Rep Article This study aimed to investigate the nutricosmetic effect of Asparagus officinalis extracts. The tip and spear of A. officinalis were successively extracted with 95% ethanol. The rutin, phenolic, and flavonoid contents of A. officinalis extracts were investigated. The antioxidant activities were determined by 2,2-azinobis (3-ethylbenzothiazoline-6-sulphonic acid) and a ferric reducing antioxidant power assay. Matrix metalloproteinase-1 (MMP-1), elastase, and hyaluronidase inhibition were determined by in vitro enzyme reaction assay. The cytotoxicity was analyzed on peripheral blood mononuclear cellss. Findings revealed that drying temperature and drying duration had significant effects on the chemical composition and biological activity of A. officinalis extract. A. officinalis tips dried at 50 °C for 24 h contained the (significantly) highest flavonoid and rutin content. The most potent extract was from A. officinalis spears since it possessed the (significantly) highest MMP-1, elastase, and hyaluronidase inhibition rates of 83.4 ± 1.5%, 70.4 ± 4.1%, and 75.2 ± 1.0%, respectively. Interestingly, at the same concentration, the A. officinalis spear extract was more potent in MMP-1 inhibition than oleanolic acid and epigallocatechin gallate, the well-known natural MMP-1 inhibitors. The results show that A. officinalis extract is an attractive source of natural anti-skin-wrinkle ingredients. Nature Publishing Group UK 2021-04-22 /pmc/articles/PMC8062454/ /pubmed/33888836 http://dx.doi.org/10.1038/s41598-021-88340-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sriyab, Suwannee
Laosirisathian, Nachtharinee
Punyoyai, Chanun
Anuchapreeda, Songyot
Tima, Singkome
Chiampanichayakul, Sawitree
Chaiyana, Wantida
Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_full Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_fullStr Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_full_unstemmed Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_short Nutricosmetic effects of Asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
title_sort nutricosmetic effects of asparagus officinalis: a potent matrix metalloproteinase-1 inhibitor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062454/
https://www.ncbi.nlm.nih.gov/pubmed/33888836
http://dx.doi.org/10.1038/s41598-021-88340-2
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