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Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study

We evaluate the risks of various urological disorders that require treatments according to obesity and metabolic health status using a nationwide dataset of the Korean population. 3,969,788 patients who had undergone health examinations were enrolled. Participants were classified as “obese” (O) or “...

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Autores principales: Kim, Jong Keun, Lee, Young Goo, Han, Kyungdo, Han, Jun Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062508/
https://www.ncbi.nlm.nih.gov/pubmed/33888807
http://dx.doi.org/10.1038/s41598-021-88165-z
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author Kim, Jong Keun
Lee, Young Goo
Han, Kyungdo
Han, Jun Hyun
author_facet Kim, Jong Keun
Lee, Young Goo
Han, Kyungdo
Han, Jun Hyun
author_sort Kim, Jong Keun
collection PubMed
description We evaluate the risks of various urological disorders that require treatments according to obesity and metabolic health status using a nationwide dataset of the Korean population. 3,969,788 patients who had undergone health examinations were enrolled. Participants were classified as “obese” (O) or “non-obese” (NO) using a BMI cut-off of 25 kg/m2. People who developed ≥ 1 metabolic disease component in the index year were considered “metabolically unhealthy” (MU), while those with none were considered “metabolically healthy” (MH). There were classified into the MHNO, MUNO, MHO, and MUO group. In BPH, chronic renal disease, neurogenic bladder, any medication related to voiding dysfunction, alpha-blocker, and antidiuretics, age and gender-adjusted hazard ratio (HR) was highest in MUO, but higher in MUNO than in MHO. In stress incontinence, prostate surgery, and 5alpha-reductase, HR increased in the order of MUNO, MHO, and MUO. In prostatitis, anti-incontinence surgery, and cystocele repair, HR was higher in MHO than MUNO and MUO. In cystitis, cystostomy, and anticholinergics, HR was higher in MUNO and MUO than MHO. In conclusion, obesity and metabolic health were individually or collaboratively involved in urological disorders related to voiding dysfunction. Metabolic healthy obesity needs to be distinguished in the diagnosis and treatment of urological disorders.
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spelling pubmed-80625082021-04-23 Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study Kim, Jong Keun Lee, Young Goo Han, Kyungdo Han, Jun Hyun Sci Rep Article We evaluate the risks of various urological disorders that require treatments according to obesity and metabolic health status using a nationwide dataset of the Korean population. 3,969,788 patients who had undergone health examinations were enrolled. Participants were classified as “obese” (O) or “non-obese” (NO) using a BMI cut-off of 25 kg/m2. People who developed ≥ 1 metabolic disease component in the index year were considered “metabolically unhealthy” (MU), while those with none were considered “metabolically healthy” (MH). There were classified into the MHNO, MUNO, MHO, and MUO group. In BPH, chronic renal disease, neurogenic bladder, any medication related to voiding dysfunction, alpha-blocker, and antidiuretics, age and gender-adjusted hazard ratio (HR) was highest in MUO, but higher in MUNO than in MHO. In stress incontinence, prostate surgery, and 5alpha-reductase, HR increased in the order of MUNO, MHO, and MUO. In prostatitis, anti-incontinence surgery, and cystocele repair, HR was higher in MHO than MUNO and MUO. In cystitis, cystostomy, and anticholinergics, HR was higher in MUNO and MUO than MHO. In conclusion, obesity and metabolic health were individually or collaboratively involved in urological disorders related to voiding dysfunction. Metabolic healthy obesity needs to be distinguished in the diagnosis and treatment of urological disorders. Nature Publishing Group UK 2021-04-22 /pmc/articles/PMC8062508/ /pubmed/33888807 http://dx.doi.org/10.1038/s41598-021-88165-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Jong Keun
Lee, Young Goo
Han, Kyungdo
Han, Jun Hyun
Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_full Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_fullStr Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_full_unstemmed Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_short Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
title_sort obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062508/
https://www.ncbi.nlm.nih.gov/pubmed/33888807
http://dx.doi.org/10.1038/s41598-021-88165-z
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