Cargando…

Progesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration

Obesity is implicated in cardiovascular disease and heart failure. When fatty acids are transported to and not adequately oxidized in cardiac cells, they accumulate, causing lipotoxicity in the heart. Since hepatic progesterone receptor membrane component 1 (Pgrmc1) suppressed de novo lipogenesis in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Sang R., Heo, Jun H., Jo, Seong Lae, Kim, Globinna, Kim, Su Jung, Yoo, Hyun Ju, Lee, Kyu-Pil, Kwun, Hyo-Jung, Shin, Hyun-Jin, Baek, In-Jeoung, Hong, Eui-Ju
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062525/ https://www.ncbi.nlm.nih.gov/pubmed/33888830 http://dx.doi.org/10.1038/s41598-021-88251-2

Ejemplares similares

Progesterone increases blood glucose via hepatic progesterone receptor membrane component 1 under limited or impaired action of insulin
por: Lee, Sang R., et al.
Publicado: (2020)

Loss of progesterone receptor membrane component 1 promotes hepatic steatosis via the induced de novo lipogenesis
por: Lee, Sang R., et al.
Publicado: (2018)

Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer
por: Lee, Sang R., et al.
Publicado: (2021)

Hepatic progesterone receptor membrane component 1 attenuates ethanol-induced liver injury by reducing acetaldehyde production and oxidative stress
por: Jo, Seong-Lae, et al.
Publicado: (2023)

MON-672 Progesterone Receptor Membrane Component 1 Suppresses Lipid Accumulation and Lipotoxicity in Animal Model of Diabetic Cardiomyopathy (DCM)
por: Lee, Sang R, et al.
Publicado: (2020)

Loss of PGRMC1 Delays the Progression of Hepatocellular Carcinoma via Suppression of Pro-Inflammatory Immune Responses
por: Lee, Sang R., et al.
Publicado: (2021)

Suppressed estrogen supply via extra-ovarian progesterone receptor membrane component 1 in menopause
por: Lee, Sang R., et al.
Publicado: (2021)

Dietary Intake of 17α-Ethinylestradiol Promotes HCC Progression in Humanized Male Mice Expressing Sex Hormone-Binding Globulin
por: Lee, Sang R., et al.
Publicado: (2021)

Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27
por: Lee, Sung Won, et al.
Publicado: (2018)

DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma
por: Kang, Hyunkoo, et al.
Publicado: (2023)

Eucommia ulmoides Cortex, Geniposide and Aucubin Regulate Lipotoxicity through the Inhibition of Lysosomal BAX
por: Lee, Geum-Hwa, et al.
Publicado: (2014)

PGRMC1 Ablation Protects from Energy-Starved Heart Failure by Promoting Fatty Acid/Pyruvate Oxidation
por: Lee, Sang R., et al.
Publicado: (2023)

Association between severe hepatic steatosis examined by Fibroscan and the risk of high-risk colorectal neoplasia
por: Kim, Kwang Woo, et al.
Publicado: (2022)

Hepatic LKB1 Reduces the Progression of Non-Alcoholic Fatty Liver Disease via Genomic Androgen Receptor Signaling
por: Heo, Jun H., et al.
Publicado: (2021)

Non-contact respiration monitoring using impulse radio ultrawideband radar in neonates
por: Kim, Jong Deok, et al.
Publicado: (2019)

Usefulness of the Controlled Attenuation Parameter for Detecting Liver Steatosis in Health Checkup Examinees
por: Kim, Ja Kyung, et al.
Publicado: (2015)

Lipotoxic Effect of p21 on Free Fatty Acid-Induced Steatosis in L02 Cells
por: Wang, Jie-wei, et al.
Publicado: (2014)

SUN-652 Progesterone Receptor Membrane Component 1 Suppresses Type II Diabetes (T2D) Progression via Induced Insulin Signaling in Muscle
por: Lee, Sang R, et al.
Publicado: (2020)

Identification of hepatic steatosis in living liver donors by machine learning models
por: Lim, Jihye, et al.
Publicado: (2022)

Dehydrozingerone inhibits renal lipotoxicity in high‐fat diet–induced obese mice
por: Lee, Eun Soo, et al.
Publicado: (2021)

(+)-Lipoic Acid Reduces Lipotoxicity and Regulates Mitochondrial Homeostasis and Energy Balance in an In Vitro Model of Liver Steatosis
por: Longhitano, Lucia, et al.
Publicado: (2023)

Letrozole Accelerates Metabolic Remodeling through Activation of Glycolysis in Cardiomyocytes: A Role beyond Hormone Regulation
por: Heo, Jun H., et al.
Publicado: (2022)

Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation
por: Jo, Seong-Lae, et al.
Publicado: (2022)

CCN5 knockout mice exhibit lipotoxic cardiomyopathy with mild obesity and diabetes
por: Kim, Jihwa, et al.
Publicado: (2018)

Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis
por: Yu, Jung Hwan, et al.
Publicado: (2016)

The Korean Mistletoe (Viscum album coloratum) Extract Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity
por: Jung, Hoe-Yune, et al.
Publicado: (2013)

Ezetimibe decreased nonalcoholic fatty liver disease activity score but not hepatic steatosis
por: Lee, Hyo Young, et al.
Publicado: (2019)

Anti-inflammatory effect of Gyeji-tang in a chronic obstructive pulmonary disease mouse model induced by cigarette smoke and lipopolysaccharide
por: Baek, Eun Bok, et al.
Publicado: (2022)

Microarray Analysis of Papillary Thyroid Cancers in Korean
por: Kim, Hyun Sook, et al.
Publicado: (2010)

Induction of Cell Cycle Arrest, Apoptosis, and Reducing the Expression of MCM Proteins in Human Lung Carcinoma A549 Cells by Cedrol, Isolated from Juniperus chinensis
por: Yun, Hee Jung, et al.
Publicado: (2022)

Efficacy of dual progesterone administration (intramuscular and vaginal) for luteal support in fresh day 3 or day 4 embryo transfer cycles
por: Nho, Eun Jee, et al.
Publicado: (2020)

Curcumae radix Reduces Endoplasmic Reticulum Stress in Mice with Chronic Neuroinflammation
por: Jo, Seong-Lae, et al.
Publicado: (2023)

Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome
por: Ge, Mengyuan, et al.
Publicado: (2023)

Lysosomal Ca(2+) as a mediator of palmitate-induced lipotoxicity
por: Oh, Soo-Jin, et al.
Publicado: (2023)

Efficient anaerobic consumption of D-xylose by E. coli BL21(DE3) via xylR adaptive mutation
por: Heo, Jung Min, et al.
Publicado: (2021)

Clusterin Protects Lipotoxicity-Induced Apoptosis via Upregulation of Autophagy in Insulin-Secreting Cells
por: Hong, Seok-Woo, et al.
Publicado: (2020)

A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis
por: Jun, Baek Gyu, et al.
Publicado: (2017)

Factors influencing serum progesterone level on triggering day in stimulated in vitro fertilization cycles
por: Park, Ju Hee, et al.
Publicado: (2015)

Detection of Abnormal Respiration from Multiple-Input Respiratory Signals
por: Kim, Ju O, et al.
Publicado: (2020)

Honokiol Improves Insulin Resistance, Hepatic Steatosis, and Inflammation in Type 2 Diabetic db/db Mice
por: Kim, Young-Je, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_quupr7naheeclog0iee6u8kvcq